Title |
The Role of Fibrocyte in the Pathogenesis of Silicosis
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Published in |
Biomedical & Environmental Sciences, April 2018
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DOI | 10.3967/bes2018.040 |
Pubmed ID | |
Authors |
Juan Li, Wu Yao, Jian Yong Hou, Lin Zhang, Lei Bao, Hui Ting Chen, Di Wang, Zhong Zheng Yue, Yi Ping Li, Miao Zhang, Xing Hao Yu, Jian Hui Zhang, Ya Qian Qu, Chang Fu Hao |
Abstract |
Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells. Fibrocytes can differentiate into myofibroblast. Therefore, the present study was designed to investigate whether fibrocytes participate in silicosis. The rat model of silicosis was established. Hematoxylin-eosin stainings and Masson stainings were used to evaluate the histopathology and collagen deposition. Flow cytometry and immunofluorescence were performed to detect the number of fibrocytes and their contribution to myofibroblasts. Results showed that fibrocytes participate in silicosis. Trend analysis of different sources of myofibroblasts during silicosis indicated that fibrocytes and lung type II epithelial cell-derived myofibroblasts play an important role in the early stage of silicosis, while resident lung fibroblast-derived myofibroblasts play a predominant role during the fibrosis formative period. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 18% |
Student > Ph. D. Student | 3 | 14% |
Student > Bachelor | 3 | 14% |
Unspecified | 1 | 5% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 9 | 41% |
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Medicine and Dentistry | 7 | 32% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Unspecified | 1 | 5% |
Environmental Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 10 | 45% |