| Title |
Moderate-Intensity Exercise Induces Neurogenesis and Improves Cognition in Old Mice by Upregulating Hippocampal Hippocalcin, Otub1, and Spectrin-α
|
|---|---|
| Published in |
Molecular Neurobiology, August 2018
|
| DOI | 10.1007/s12035-018-1239-x |
| Pubmed ID | |
| Authors |
Ji Hyun Kim, Quan Feng Liu, Enerelt Urnuhsaikhan, Ha Jin Jeong, Mi Yang Jeon, Songhee Jeon |
| Abstract |
Exercise increases the levels of neurogenic factors and enhances neurogenesis, memory, and learning. However, the molecular link between exercise and neurogenesis is not clear. The purpose of this study was to examine the effects of exercise intensity on cognitive function and protein expression in the hippocampus of old mice. To compare the effects of aerobic exercise intensity on cognition in old mice, we exposed 18-month-old mice to low- and moderate-intensity treadmill exercise for 4 weeks. Moderate-intensity exercise improved cognitive function in the old mice, while low-intensity exercise did not. To investigate the underlying mechanisms, two-dimensional electrophoresis was used to examine protein expression. Using peptide fingerprinting mass spectrometry, we identified 19 proteins that were upregulated in the hippocampus following exercise training, and seven of these proteins were normalized by the control value. Among them, the levels of 14-3-3 zeta and heat shock protein 70, which have been shown to be induced by exercise training and related to neurogenesis, were dramatically increased by moderate exercise. Hippocalcin, α-spectrin, ovarian tumor domain-containing ubiquitin aldehyde-binding protein 1 (otub1), mu-crystallin, serine racemase, and rho GDP dissociation inhibitor 1, which are related to neurogenesis, neuroprotection, and synaptic strength, were upregulated in the hippocampus by moderate exercise. In addition, we confirmed that neurogenic markers, including doublecortin and the neuronal nuclei antigen, and hippocalcin, otub1, and spectrin-α are potential molecular links between hippocampal neurogenesis and exercise in the elderly. Thus, these results showed that steady moderate-intensity exercise delayed the declines in cognitive function in the elderly through the activation of multiple factors. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 15% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Master | 7 | 10% |
| Researcher | 4 | 6% |
| Student > Doctoral Student | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 27 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 12% |
| Nursing and Health Professions | 6 | 9% |
| Agricultural and Biological Sciences | 5 | 7% |
| Psychology | 5 | 7% |
| Medicine and Dentistry | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 29 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2019.
All research outputs
#17,987,106
of 23,099,576 outputs
Outputs from Molecular Neurobiology
#2,360
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Outputs of similar age
#238,030
of 331,157 outputs
Outputs of similar age from Molecular Neurobiology
#88
of 126 outputs
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