Title |
Plasma prolactin levels are associated with the severity of illness in drug-naive first-episode psychosis female patients
|
---|---|
Published in |
Archives of Women's Mental Health, August 2018
|
DOI | 10.1007/s00737-018-0899-x |
Pubmed ID | |
Authors |
Manuel Delgado-Alvarado, Diana Tordesillas-Gutierrez, Rosa Ayesa-Arriola, Manuel Canal, Victor Ortiz-García de la Foz, Javier Labad, Benedicto Crespo-Facorro |
Abstract |
Patients with schizophrenia frequently present hyperprolactinemia as a consequence of antipsychotic treatment. However, an increase in circulating prolactin levels has also been shown in patients without previous treatment. Our objective was to compare prolactin levels between antipsychotic-naive first-episode psychosis (AN-FEP) patients and healthy controls (HC). As part of an FEP program (Programa Asistencial Fases Iniciales de Psicosis [PAFIP]), 270 AN-FEP patients and 153 HC were eligible for this study. Serum prolactin levels were measured by an automated immunochemiluminescent assay. Subjects' sex and having an AN-FEP diagnosis both had an effect on prolactin levels, with higher levels in women than in men, and in AN-FEP patients than in HC. Moreover, plasma prolactin levels showed a negative correlation with the SAPS scores in AN-FEP female patients. AN-FEP patients have increased levels of prolactin, which might be stress-induced. This, together with the association of higher prolactin with a lower severity of the disease, suggests that prolactin might play a neuroprotective role, especially in women. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 24% |
Student > Postgraduate | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Student > Bachelor | 3 | 7% |
Student > Master | 3 | 7% |
Other | 3 | 7% |
Unknown | 16 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 21% |
Neuroscience | 5 | 12% |
Psychology | 4 | 10% |
Social Sciences | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 1 | 2% |
Unknown | 20 | 48% |