Title |
Population structures of Leishmania infantum and Leishmania tropica the causative agents of kala-azar in Southwest Iran
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Published in |
Parasitology Research, August 2018
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DOI | 10.1007/s00436-018-6041-1 |
Pubmed ID | |
Authors |
Mohammad Amin Ghatee, Hossein Mirhendi, Mehdi Karamian, Walter R. Taylor, Iraj Sharifi, Massood Hosseinzadeh, Zahra Kanannejad |
Abstract |
Visceral leishmaniasis (VL) is endemic in Iran and is caused predominantly by Leishmania infantum, but L. tropica is emerging as an important cause. We studied the intra-species population structure of Leishmania spp. causing VL in southwest Iran by sequence analysis of the internal transcribed spacer (ITS) 1 of DNA samples from 29 bone marrow aspiration smears. L. infantum (n = 25) and L. tropica (n = 4) were identified, consisting of 10 and three ITS1 sequence types (STs), respectively. Compared to GenBank ITS1 STs, our L. infantum parasites displayed high heterogeneity but less heterogeneity compared than northwest Iranian isolates. VL affects mostly nomadic populations in southwest Iran, and their mobility may explain partly the L. infantum heterogeneity. The VL causing L. tropica was also genetically heterogeneous but genetically indistinguishable from L. tropica strains causing anthroponotic cutaneous leishmaniasis from southwest Iran. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 19% |
Student > Bachelor | 3 | 11% |
Other | 2 | 7% |
Researcher | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 4 | 15% |
Unknown | 9 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 15% |
Agricultural and Biological Sciences | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Social Sciences | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Other | 5 | 19% |
Unknown | 9 | 33% |