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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain
|
|---|---|
| Published in |
eLife, October 2015
|
| DOI | 10.7554/elife.08422 |
| Pubmed ID | |
| Authors |
L Shahul Hameed, Daniel A Berg, Laure Belnoue, Lasse D Jensen, Yihai Cao, András Simon |
| Abstract |
Organisms need to adapt to the ecological constraints in their habitat. How specific processes reflect such adaptations are difficult to model experimentally. We tested whether environmental shifts in oxygen tension lead to events in the adult newt brain that share features with processes occuring during neuronal regeneration under normoxia. By experimental simulation of varying oxygen concentrations we show that hypoxia followed by re-oxygenation lead to neuronal death and hallmarks of an injury response, including activation of neural stem cells ultimately leading to neurogenesis. Neural stem cells accumulate reactive oxygen species (ROS) during re-oxygenation and inhibition of ROS biosynthesis counteracts their proliferation as well as neurogenesis. Importantly, regeneration of dopamine neurons under normoxia also depends on ROS-production. These data demonstrate a role for ROS-production in neurogenesis in newts, and suggest that this role may have been recruited to the capacity to replace lost neurons in the brain of an adult vertebrate. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| United Kingdom | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Scientists | 3 | 43% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 90 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 26% |
| Researcher | 16 | 17% |
| Student > Bachelor | 14 | 15% |
| Student > Master | 11 | 12% |
| Other | 5 | 5% |
| Other | 15 | 16% |
| Unknown | 7 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 34% |
| Biochemistry, Genetics and Molecular Biology | 22 | 24% |
| Neuroscience | 15 | 16% |
| Materials Science | 3 | 3% |
| Medicine and Dentistry | 3 | 3% |
| Other | 4 | 4% |
| Unknown | 14 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2019.
All research outputs
#8,249,082
of 25,376,589 outputs
Outputs from eLife
#11,864
of 15,564 outputs
Outputs of similar age
#96,492
of 294,354 outputs
Outputs of similar age from eLife
#176
of 255 outputs
Altmetric has tracked 25,376,589 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 15,564 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.1. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,354 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.