Chapter title |
Lactobacillus: Host-Microbe Relationships.
|
---|---|
Chapter number | 187 |
Book title |
Between Pathogenicity and Commensalism
|
Published in |
Current topics in microbiology and immunology, November 2011
|
DOI | 10.1007/82_2011_187 |
Pubmed ID | |
Book ISBNs |
978-3-64-236559-1, 978-3-64-236560-7
|
Authors |
John O’Callaghan, Paul W. O’Toole, O’Callaghan, John, O’Toole, Paul W. |
Abstract |
Lactobacilli are a subdominant component of the human intestinal microbiota that are also found in other body sites, certain foods, and nutrient-rich niches in the free environment. They represent the types of microorganisms that mammalian immune systems have learned not to react to, which is recognized as a potential driving force in the evolution of the human immune system. Co-evolution of lactobacilli and animals provides a rational basis to postulate an association with health benefits. To further complicate a description of their host interactions, lactobacilli may rarely cause opportunistic infections in compromised subjects. In this review, we focus primarily on human-Lactobacillus interactions. We overview the microbiological complexity of this extraordinarily diverse genus, we describe where lactobacilli are found in or on humans, what responses their presence elicits, and what microbial interaction and effector molecules have been identified. The rare cases of Lactobacillus septicaemia are explained in terms of the host impairment required for such an outcome. We discuss possibilities for exploitation of lactobacilli for therapeutic delivery and mucosal vaccination. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 1% |
Switzerland | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 94 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 13% |
Student > Ph. D. Student | 11 | 11% |
Student > Doctoral Student | 11 | 11% |
Researcher | 9 | 9% |
Student > Master | 8 | 8% |
Other | 8 | 8% |
Unknown | 37 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 21% |
Biochemistry, Genetics and Molecular Biology | 11 | 11% |
Medicine and Dentistry | 10 | 10% |
Immunology and Microbiology | 7 | 7% |
Nursing and Health Professions | 2 | 2% |
Other | 6 | 6% |
Unknown | 41 | 42% |