| Title |
Impact of daily incremental change in environmental temperature on beta cell function and the risk of gestational diabetes in pregnant women
|
|---|---|
| Published in |
Diabetologia, August 2018
|
| DOI | 10.1007/s00125-018-4710-3 |
| Pubmed ID | |
| Authors |
Ravi Retnakaran, Chang Ye, Caroline K. Kramer, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer, Bernard Zinman |
| Abstract |
The prevalence of gestational diabetes (GDM) is higher in summer months, possibly reflecting an association between ambient temperature and blood glucose levels. However, the specific exposure and mechanism by which temperature may affect glucose metabolism in pregnancy remains unclear. We systematically evaluated the relationships of environmental temperature and changes therein over varying durations of exposure time with beta cell function, insulin sensitivity and glucose tolerance in women undergoing antepartum screening for GDM. At a mean gestation of 29 weeks, 1464 women in Toronto (ON, Canada) underwent an OGTT, from which 318 were diagnosed with GDM. Blood glucose, beta cell function and insulin sensitivity were evaluated in relation to 18 temperature variables: mean temperature and change in temperature on the day of the OGTT and over the preceding 7, 14, 21, 28, 35, 42, 49 and 56 days, respectively. Temperature changes in the preceding 14, 21, 28, 35, 42, 49 and 56 days (rather than mean temperatures) emerged as independent predictors of blood glucose. These relationships were evident in months where mean daily temperature was rising (February - July), but not in those where it was falling (August - January). Indeed, in February - July, the temperature changes in the preceding 21, 28 and 35 days emerged as predictors of both poorer beta cell function and higher blood glucose. Moreover, in February - July, the changes in temperature in the preceding 21 days (OR 1.16, 95% CI 1.01, 1.33) and 28 days (OR 1.20, 95% CI 1.03, 1.39) were independent predictors of GDM, while mean temperatures were not. In pregnant women, rising environmental temperature in the 3-4 weeks prior to glucose tolerance testing may be associated with beta cell dysfunction and an increased risk of GDM. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 20% |
| United Kingdom | 3 | 12% |
| United States | 2 | 8% |
| Canada | 2 | 8% |
| Brazil | 1 | 4% |
| India | 1 | 4% |
| Guadeloupe | 1 | 4% |
| Unknown | 10 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 80% |
| Scientists | 3 | 12% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 33% |
| Researcher | 3 | 13% |
| Professor | 3 | 13% |
| Student > Bachelor | 2 | 8% |
| Student > Ph. D. Student | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 21% |
| Nursing and Health Professions | 4 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Environmental Science | 2 | 8% |
| Earth and Planetary Sciences | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 6 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2022.
All research outputs
#2,600,025
of 24,752,377 outputs
Outputs from Diabetologia
#1,325
of 5,295 outputs
Outputs of similar age
#51,381
of 335,490 outputs
Outputs of similar age from Diabetologia
#36
of 66 outputs
Altmetric has tracked 24,752,377 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
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