Title |
Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus
|
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Published in |
Immunologic Research, October 2015
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DOI | 10.1007/s12026-015-8716-3 |
Pubmed ID | |
Authors |
Meggan Mackay |
Abstract |
Cognitive disturbances, mood disorders and fatigue are common in SLE patients with substantial adverse effects on function and quality of life. Attribution of these clinical findings to immune-mediated disturbances associated with SLE remains difficult and has compromised research efforts in these areas. Improved understanding of the role of the immune system in neurologic processes essential for cognition including synaptic plasticity, long term potentiation and adult neurogenesis suggests multiple potential mechanisms for altered central nervous system function associated with a chronic inflammatory illness such as SLE. This review will focus on the biology of cognition and neuroinflammation in normal circumstances and potential biologic mechanisms for cognitive impairment, depression and fatigue attributable to SLE. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 38% |
United States | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 4 | 50% |
Members of the public | 3 | 38% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 95 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 16 | 17% |
Student > Bachelor | 12 | 13% |
Other | 11 | 12% |
Researcher | 10 | 11% |
Student > Postgraduate | 6 | 6% |
Other | 16 | 17% |
Unknown | 24 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 37% |
Psychology | 14 | 15% |
Agricultural and Biological Sciences | 6 | 6% |
Social Sciences | 3 | 3% |
Immunology and Microbiology | 2 | 2% |
Other | 8 | 8% |
Unknown | 27 | 28% |