| Title |
Venous Thromboembolic Events Following Major Pelvic and Abdominal Surgeries for Cancer: A Prospective Cohort Study
|
|---|---|
| Published in |
Annals of Surgical Oncology, July 2018
|
| DOI | 10.1245/s10434-018-6671-7 |
| Pubmed ID | |
| Authors |
Pablo E. Serrano, Sameer Parpia, Lori-Ann Linkins, Laurie Elit, Marko Simunovic, Leyo Ruo, Mohit Bhandari, Mark Levine |
| Abstract |
The aim of this study was to evaluate the incidence and risk factors for post-hospital discharge venous thromboembolism (VTE) following abdominal cancer surgery without post-discharge prophylaxis. This was a single-center, prospective cohort study. Patients were evaluated at 1, 3, and 6 months from surgery for the presence of proximal deep vein thrombosis (DVT; screening ultrasound at 1 month and questionnaire at each visit). Cumulative VTE incidence with 95% confidence interval (CI) was estimated using Kaplan-Meier methods, and multivariable analysis was performed using a Cox proportional hazards model. Of 284 patients enrolled, 79 (28%) underwent colorectal laparotomy, 97 (34%) underwent hepatobiliary laparotomy, 100 (35%) underwent gynecological laparotomy, and 8 (3%) underwent exploratory laparotomy without resection. All patients received pre- and postoperative inpatient prophylaxis. The cumulative incidence of VTE at 1 month was 0.35% (95% CI 0.05-2.48), 2.5% at 3 months (95% CI 1.19-5.15), and 7.2% at 6 months (95% CI 4.72-10.97). Screening ultrasound performed 4 weeks after surgery in 50% of patients was negative for thrombosis in all cases. Event distribution was similar according to the type of surgery (open/laparoscopic) and type of cancer. Seventeen (6.6%) patients died (95% CI 3.5-9.4) (two had a VTE-related death). Postoperative chemotherapy and Caprini score were significantly associated with VTE [hazard ratios 3.77 (95% CI 1.56-9.12) and 1.17 (95% CI 1.02-1.34), respectively]. The incidence of post-hospital discharge proximal DVT and/or symptomatic VTE following abdominal and pelvic cancer surgery appears to be low. The cumulative number of events increased at 6 months, but this was likely due to additional risk factors that were not related to surgery. Postoperative chemotherapy increases the risk of VTE. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 16% |
| Student > Ph. D. Student | 7 | 14% |
| Other | 5 | 10% |
| Student > Doctoral Student | 3 | 6% |
| Researcher | 3 | 6% |
| Other | 10 | 20% |
| Unknown | 14 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 38% |
| Nursing and Health Professions | 4 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Unspecified | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 19 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2022.
All research outputs
#13,059,047
of 23,009,818 outputs
Outputs from Annals of Surgical Oncology
#3,637
of 6,535 outputs
Outputs of similar age
#158,779
of 330,110 outputs
Outputs of similar age from Annals of Surgical Oncology
#83
of 126 outputs
Altmetric has tracked 23,009,818 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.