| Title |
Calcium channel gating
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, June 2018
|
| DOI | 10.1007/s00424-018-2163-7 |
| Pubmed ID | |
| Authors |
S. Hering, E.-M. Zangerl-Plessl, S. Beyl, A. Hohaus, S. Andranovits, E. N. Timin |
| Abstract |
Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gates which open during membrane depolarizations and seal the pore at rest. The gating process is determined by distinct sub-processes: movement of voltage-sensing domains (charged S4 segments) as well as opening and closure of S6 gates. Neutralization of S4 charges revealed that pore opening of CaV1.2 is triggered by a "gate releasing" movement of all four S4 segments with activation of IS4 (and IIIS4) being a rate-limiting stage. Segment IS4 additionally plays a crucial role in channel inactivation. Remarkably, S4 segments carrying only a single charged residue efficiently participate in gating. However, the complete set of S4 charges is required for stabilization of the open state. Voltage clamp fluorometry, the cryo-EM structure of a mammalian calcium channel, biophysical and pharmacological studies, and mathematical simulations have all contributed to a novel interpretation of the role of voltage sensors in channel opening, closure, and inactivation. We illustrate the role of the different methodologies in gating studies and discuss the key molecular events leading CaV channels to open and to close. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Student > Bachelor | 10 | 13% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 7 | 9% |
| Researcher | 6 | 8% |
| Other | 9 | 11% |
| Unknown | 22 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 22% |
| Neuroscience | 11 | 14% |
| Agricultural and Biological Sciences | 10 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Medicine and Dentistry | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2018.
All research outputs
#14,891,567
of 23,818,521 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,272
of 1,973 outputs
Outputs of similar age
#189,173
of 330,550 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#6
of 23 outputs
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