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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer
|
|---|---|
| Published in |
EMBO Molecular Medicine, August 2018
|
| DOI | 10.15252/emmm.201708566 |
| Pubmed ID | |
| Authors |
Murugan Kalimutho, Debottam Sinha, Jessie Jeffery, Katia Nones, Sriganesh Srihari, Winnie C Fernando, Pascal HG Duijf, Claire Vennin, Prahlad Raninga, Devathri Nanayakkara, Deepak Mittal, Jodi M Saunus, Sunil R Lakhani, J Alejandro López, Kevin J Spring, Paul Timpson, Brian Gabrielli, Nicola Waddell, Kum Kum Khanna |
| Abstract |
The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive. Here, we showed that CEP55 overexpression/knockdown impacts survival of aneuploid cells. Loss of CEP55 sensitizes breast cancer cells to anti-mitotic agents through premature CDK1/cyclin B activation and CDK1 caspase-dependent mitotic cell death. Further, we showed that CEP55 is a downstream effector of the MEK1/2-MYC axis. Blocking MEK1/2-PLK1 signaling therefore reduced outgrowth of basal-like syngeneic and human breast tumors in in vivo models. In conclusion, high CEP55 levels dictate cell fate during perturbed mitosis. Forced mitotic cell death by blocking MEK1/2-PLK1 represents a potential therapeutic strategy for MYC-CEP55-dependent basal-like, triple-negative breast cancers. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 5 | 63% |
| Germany | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Science communicators (journalists, bloggers, editors) | 2 | 25% |
| Scientists | 1 | 13% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 18% |
| Student > Master | 7 | 18% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Bachelor | 4 | 10% |
| Professor | 3 | 8% |
| Other | 5 | 13% |
| Unknown | 8 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 31% |
| Agricultural and Biological Sciences | 5 | 13% |
| Medicine and Dentistry | 4 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Arts and Humanities | 1 | 3% |
| Other | 5 | 13% |
| Unknown | 10 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2019.
All research outputs
#4,216,095
of 23,835,032 outputs
Outputs from EMBO Molecular Medicine
#769
of 1,520 outputs
Outputs of similar age
#78,742
of 332,565 outputs
Outputs of similar age from EMBO Molecular Medicine
#18
of 34 outputs
Altmetric has tracked 23,835,032 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,520 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.2. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,565 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.