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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
|
|---|---|
| Published in |
Nature Cell Biology, January 2010
|
| DOI | 10.1038/ncb2013 |
| Pubmed ID | |
| Authors |
Gianluca Canettieri, Lucia Di Marcotullio, Azzura Greco, Sonia Coni, Laura Antonucci, Paola Infante, Laura Pietrosanti, Enrico De Smaele, Elisabetta Ferretti, Evelina Miele, Marianna Pelloni, Giuseppina De Simone, Emilia Maria Pedone, Paola Gallinari, Alessandra Giorgi, Christian Steinkühler, Luigi Vitagliano, Carlo Pedone, M. Eugenià Schinin, Isabella Screpanti, Alberto Gulino |
| Abstract |
Hedgehog signalling is crucial for development and is deregulated in several tumours, including medulloblastoma. Regulation of the transcriptional activity of Gli (glioma-associated oncogene) proteins, effectors of the Hedgehog pathway, is poorly understood. We show here that Gli1 and Gli2 are acetylated proteins and that their HDAC-mediated deacetylation promotes transcriptional activation and sustains a positive autoregulatory loop through Hedgehog-induced upregulation of HDAC1. This mechanism is turned off by HDAC1 degradation through an E3 ubiquitin ligase complex formed by Cullin3 and REN, a Gli antagonist lost in human medulloblastoma. Whereas high HDAC1 and low REN expression in neural progenitors and medulloblastomas correlates with active Hedgehog signalling, loss of HDAC activity suppresses Hedgehog-dependent growth of neural progenitors and tumour cells. Consistent with this, abrogation of Gli1 acetylation enhances cellular proliferation and transformation. These data identify an integrated HDAC- and ubiquitin-mediated circuitry, where acetylation of Gli proteins functions as an unexpected key transcriptional checkpoint of Hedgehog signalling. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 2% |
| United States | 3 | 2% |
| Italy | 1 | <1% |
| China | 1 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 171 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 24% |
| Researcher | 38 | 21% |
| Student > Bachelor | 19 | 10% |
| Student > Master | 12 | 7% |
| Professor > Associate Professor | 9 | 5% |
| Other | 31 | 17% |
| Unknown | 29 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 74 | 41% |
| Biochemistry, Genetics and Molecular Biology | 42 | 23% |
| Medicine and Dentistry | 12 | 7% |
| Neuroscience | 8 | 4% |
| Chemistry | 6 | 3% |
| Other | 6 | 3% |
| Unknown | 34 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2011.
All research outputs
#15,239,825
of 22,659,164 outputs
Outputs from Nature Cell Biology
#3,255
of 3,812 outputs
Outputs of similar age
#134,529
of 164,481 outputs
Outputs of similar age from Nature Cell Biology
#33
of 38 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,481 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.