| Title |
Hypoxia regulates the hematopoietic stem cell niche
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, October 2015
|
| DOI | 10.1007/s00424-015-1743-z |
| Pubmed ID | |
| Authors |
Takayuki Morikawa, Keiyo Takubo |
| Abstract |
Bone marrow, the site of hematopoiesis throughout adulthood, is a physiologically hypoxic organ. Thus, various biological oxygen sensors and their signaling cascades play a pivotal role in hematopoietic systems in the bone marrow under both physiologic and pathologic conditions. Hypoxia-inducible factors (HIFs) are hypoxic stress sensor proteins that are stabilized under homeostatic or stress-induced hypoxia. In the hypoxic bone marrow, HIFs play crucial roles in hematopoietic stem cells (HSCs) and in the cells of the HSC niche. The signals downstream of the HIFs maintain HSC quiescence, survival, and metabolic homeostasis through both cell-autonomous and non-cell-autonomous mechanisms. Leukemic stem cells (LSCs) hijack these delicate hypoxia-sensing mechanisms to sustain their self-renewal potential, promoting disease progression and drug resistance even under normoxic conditions. This review focuses on HIF-mediated oxygen-sensing mechanisms of adult HSCs and LSCs and their niche cells in the hypoxic bone marrow. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Unknown | 102 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 25% |
| Researcher | 16 | 15% |
| Student > Master | 15 | 14% |
| Student > Bachelor | 12 | 11% |
| Student > Doctoral Student | 9 | 9% |
| Other | 11 | 10% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 32 | 30% |
| Agricultural and Biological Sciences | 30 | 29% |
| Medicine and Dentistry | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Engineering | 3 | 3% |
| Other | 8 | 8% |
| Unknown | 20 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2015.
All research outputs
#14,889,699
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,272
of 1,973 outputs
Outputs of similar age
#149,752
of 284,929 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#7
of 18 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.