Title |
Genome-wide genetic homogeneity between sexes and populations for human height and body mass index
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Published in |
Human Molecular Genetics, October 2015
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DOI | 10.1093/hmg/ddv443 |
Pubmed ID | |
Authors |
Jian Yang, Andrew Bakshi, Zhihong Zhu, Gibran Hemani, Anna A E Vinkhuyzen, Ilja M Nolte, Jana V van Vliet-Ostaptchouk, Harold Snieder, Tonu Esko, Lili Milani, Reedik Mägi, Andres Metspalu, Anders Hamsten, Patrik K E Magnusson, Nancy L Pedersen, Erik Ingelsson, Peter M Visscher |
Abstract |
Sex-specific genetic effects have been proposed to be an important source of variation for human complex traits. Here we use two distinct genome-wide methods to estimate the autosomal genetic correlation (rg) between men and women for human height and body mass index, using individual-level (n=∼44,000) and summary-level (n=∼133,000) data from genome-wide association studies. Results are consistent and show that the between-sex genetic correlation is not significantly different from unity for both traits. In contrast, we find evidence of genetic heterogeneity between sexes for waist-hip-ratio (rg=∼0.7) and between populations for BMI (rg=∼0.9 between Europe and the USA) but not for height. The lack of evidence for substantial genetic heterogeneity for body size is consistent with empirical findings across traits and species. |
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