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Genome-wide genetic homogeneity between sexes and populations for human height and body mass index

Overview of attention for article published in Human Molecular Genetics, October 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 news outlet
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3 X users

Citations

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83 Mendeley
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1 CiteULike
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Title
Genome-wide genetic homogeneity between sexes and populations for human height and body mass index
Published in
Human Molecular Genetics, October 2015
DOI 10.1093/hmg/ddv443
Pubmed ID
Authors

Jian Yang, Andrew Bakshi, Zhihong Zhu, Gibran Hemani, Anna A E Vinkhuyzen, Ilja M Nolte, Jana V van Vliet-Ostaptchouk, Harold Snieder, Tonu Esko, Lili Milani, Reedik Mägi, Andres Metspalu, Anders Hamsten, Patrik K E Magnusson, Nancy L Pedersen, Erik Ingelsson, Peter M Visscher

Abstract

Sex-specific genetic effects have been proposed to be an important source of variation for human complex traits. Here we use two distinct genome-wide methods to estimate the autosomal genetic correlation (rg) between men and women for human height and body mass index, using individual-level (n=∼44,000) and summary-level (n=∼133,000) data from genome-wide association studies. Results are consistent and show that the between-sex genetic correlation is not significantly different from unity for both traits. In contrast, we find evidence of genetic heterogeneity between sexes for waist-hip-ratio (rg=∼0.7) and between populations for BMI (rg=∼0.9 between Europe and the USA) but not for height. The lack of evidence for substantial genetic heterogeneity for body size is consistent with empirical findings across traits and species.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Unknown 81 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 27%
Student > Ph. D. Student 20 24%
Student > Master 12 14%
Student > Bachelor 7 8%
Student > Doctoral Student 4 5%
Other 10 12%
Unknown 8 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 30%
Biochemistry, Genetics and Molecular Biology 22 27%
Medicine and Dentistry 8 10%
Psychology 7 8%
Social Sciences 4 5%
Other 6 7%
Unknown 11 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2016.
All research outputs
#3,343,207
of 25,837,817 outputs
Outputs from Human Molecular Genetics
#1,187
of 8,398 outputs
Outputs of similar age
#44,223
of 296,623 outputs
Outputs of similar age from Human Molecular Genetics
#75
of 136 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,398 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.