| Title |
Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease
|
|---|---|
| Published in |
Digestive Diseases and Sciences, August 2018
|
| DOI | 10.1007/s10620-018-5242-x |
| Pubmed ID | |
| Authors |
Akshay Shetty, Jennifer W. Hsu, Paul P. Manka, Wing-Kin Syn |
| Abstract |
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized nations and is strongly associated with the metabolic syndrome. The prevalence of NAFLD continues to rise along with the epidemic of the metabolic syndrome. Metabolic homeostasis is linked to the circadian clock (rhythm), with multiple signaling pathways in organs regulated by circadian clock genes, and recent studies of circadian clock gene functions suggest that disruption of the circadian rhythm is associated with significant morbidity and mortality, including the metabolic syndrome. In the industrialized world, various human behaviors and activities such as work and eating patterns, jet lag, and sleep deprivation interfere with the circadian rhythm, leading to perturbations in metabolism and development of the metabolic syndrome. In this review, we discuss how disruption of the circadian rhythm is associated with various metabolic conditions that comprise the metabolic syndrome and NAFLD. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 67% |
| Mexico | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 14% |
| Student > Bachelor | 15 | 12% |
| Student > Ph. D. Student | 12 | 10% |
| Researcher | 10 | 8% |
| Other | 7 | 6% |
| Other | 20 | 17% |
| Unknown | 40 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 19% |
| Biochemistry, Genetics and Molecular Biology | 17 | 14% |
| Nursing and Health Professions | 11 | 9% |
| Agricultural and Biological Sciences | 6 | 5% |
| Neuroscience | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 48 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2022.
All research outputs
#1,807,017
of 25,519,924 outputs
Outputs from Digestive Diseases and Sciences
#170
of 4,682 outputs
Outputs of similar age
#36,567
of 341,874 outputs
Outputs of similar age from Digestive Diseases and Sciences
#4
of 69 outputs
Altmetric has tracked 25,519,924 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,682 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,874 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.