Title |
Present Status of Brugada Syndrome JACC State-of-the-Art Review
|
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Published in |
JACC, August 2018
|
DOI | 10.1016/j.jacc.2018.06.037 |
Pubmed ID | |
Authors |
Josep Brugada, Oscar Campuzano, Elena Arbelo, Georgia Sarquella-Brugada, Ramon Brugada |
Abstract |
The Brugada syndrome is an inherited disorder associated with risk of ventricular fibrillation and sudden cardiac death in a structurally normal heart. Diagnosis is based on a characteristic electrocardiographic pattern (coved type ST-segment elevation ≥2 mm followed by a negative T-wave in ≥1 of the right precordial leads V1 to V2), observed either spontaneously or during a sodium-channel blocker test. The prevalence varies among regions and ethnicities, affecting mostly males. The risk stratification and management of patients, principally asymptomatic, still remains challenging. The current main therapy is an implantable cardioverter-defibrillator, but radiofrequency catheter ablation has been recently reported as an effective new treatment. Since its first description in 1992, continuous achievements have expanded our understanding of the genetics basis and electrophysiological mechanisms underlying the disease. Currently, despite several genes identified, SCN5A has attracted most attention, and in approximately 30% of patients, a genetic variant may be implicated in causation after a comprehensive analysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 60 | 19% |
United States | 24 | 7% |
Mexico | 19 | 6% |
Venezuela, Bolivarian Republic of | 15 | 5% |
Colombia | 15 | 5% |
Argentina | 11 | 3% |
Chile | 6 | 2% |
Ecuador | 5 | 2% |
United Kingdom | 4 | 1% |
Other | 39 | 12% |
Unknown | 125 | 39% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 245 | 76% |
Practitioners (doctors, other healthcare professionals) | 42 | 13% |
Scientists | 19 | 6% |
Science communicators (journalists, bloggers, editors) | 17 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 378 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 11% |
Other | 37 | 10% |
Student > Postgraduate | 37 | 10% |
Student > Bachelor | 33 | 9% |
Student > Ph. D. Student | 30 | 8% |
Other | 73 | 19% |
Unknown | 128 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 170 | 45% |
Biochemistry, Genetics and Molecular Biology | 19 | 5% |
Agricultural and Biological Sciences | 6 | 2% |
Nursing and Health Professions | 4 | 1% |
Engineering | 4 | 1% |
Other | 23 | 6% |
Unknown | 152 | 40% |