Title |
Scaffold and scaffold‐free self‐assembled systems in regenerative medicine
|
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Published in |
Biotechnology & Bioengineering, November 2015
|
DOI | 10.1002/bit.25869 |
Pubmed ID | |
Authors |
Dilip Thomas, Diana Gaspar, Anna Sorushanova, Gesmi Milcovich, Kyriakos Spanoudes, Anne Maria Mullen, Timothy O'Brien, Abhay Pandit, Dimitrios I. Zeugolis |
Abstract |
Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes. This article is protected by copyright. All rights reserved. |
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Geographical breakdown
Country | Count | As % |
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Japan | 1 | 1% |
China | 1 | 1% |
Australia | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 15 | 20% |
Researcher | 14 | 19% |
Student > Ph. D. Student | 10 | 14% |
Student > Bachelor | 9 | 12% |
Professor | 4 | 5% |
Other | 13 | 18% |
Unknown | 9 | 12% |
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Engineering | 12 | 16% |
Materials Science | 8 | 11% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Medicine and Dentistry | 5 | 7% |
Other | 10 | 14% |
Unknown | 17 | 23% |