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Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future

Overview of attention for article published in British Journal of Clinical Pharmacology, October 2015
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Title
Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future
Published in
British Journal of Clinical Pharmacology, October 2015
DOI 10.1111/bcp.12741
Pubmed ID
Authors

Kate O'Hara, Ian M R Wright, Jennifer J Schneider, Alison L Jones, Jennifer H Martin

Abstract

Paediatric patients, particularly preterm neonates, present many pharmacological challenges. Due to the difficulty in conducting clinical trials in these populations dosing information is often extrapolated from adult populations. As the processes of absorption, distribution, metabolism and excretion of drugs change throughout growth and development extrapolation presents risk of over or underestimating the doses required. Information about the development these processes, particularly drug metabolism pathways, is still limited with weight based dose adjustment presenting the best method of estimating pharmacokinetic changes due to growth and development. New innovations in pharmacokinetic research, such as population pharmacokinetic modelling, present unique opportunities to conduct clinical trials in these populations improving the safety and effectiveness of the drugs used. More research is required into this area to ensure the best outcomes for our most vulnerable patients. This article is protected by copyright. All rights reserved.

X Demographics

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 131 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 14%
Researcher 16 12%
Student > Bachelor 14 11%
Other 9 7%
Student > Postgraduate 7 5%
Other 27 21%
Unknown 40 31%
Readers by discipline Count As %
Medicine and Dentistry 35 27%
Pharmacology, Toxicology and Pharmaceutical Science 26 20%
Nursing and Health Professions 11 8%
Biochemistry, Genetics and Molecular Biology 4 3%
Chemistry 3 2%
Other 8 6%
Unknown 44 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2015.
All research outputs
#14,644,315
of 24,558,777 outputs
Outputs from British Journal of Clinical Pharmacology
#3,676
of 5,389 outputs
Outputs of similar age
#140,747
of 290,146 outputs
Outputs of similar age from British Journal of Clinical Pharmacology
#37
of 57 outputs
Altmetric has tracked 24,558,777 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,146 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.