Title |
Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future
|
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Published in |
British Journal of Clinical Pharmacology, October 2015
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DOI | 10.1111/bcp.12741 |
Pubmed ID | |
Authors |
Kate O'Hara, Ian M R Wright, Jennifer J Schneider, Alison L Jones, Jennifer H Martin |
Abstract |
Paediatric patients, particularly preterm neonates, present many pharmacological challenges. Due to the difficulty in conducting clinical trials in these populations dosing information is often extrapolated from adult populations. As the processes of absorption, distribution, metabolism and excretion of drugs change throughout growth and development extrapolation presents risk of over or underestimating the doses required. Information about the development these processes, particularly drug metabolism pathways, is still limited with weight based dose adjustment presenting the best method of estimating pharmacokinetic changes due to growth and development. New innovations in pharmacokinetic research, such as population pharmacokinetic modelling, present unique opportunities to conduct clinical trials in these populations improving the safety and effectiveness of the drugs used. More research is required into this area to ensure the best outcomes for our most vulnerable patients. This article is protected by copyright. All rights reserved. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 50% |
Spain | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 131 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 18 | 14% |
Researcher | 16 | 12% |
Student > Bachelor | 14 | 11% |
Other | 9 | 7% |
Student > Postgraduate | 7 | 5% |
Other | 27 | 21% |
Unknown | 40 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 26 | 20% |
Nursing and Health Professions | 11 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Chemistry | 3 | 2% |
Other | 8 | 6% |
Unknown | 44 | 34% |