| Title |
Treatment of colorectal liver metastases
|
|---|---|
| Published in |
World Journal of Surgical Oncology, November 2011
|
| DOI | 10.1186/1477-7819-9-154 |
| Pubmed ID | |
| Authors |
Nabil Ismaili |
| Abstract |
Colorectal cancer (CRC) is the third most common cancer in the word. Liver metastasis is the most common site of colorectal metastases. The prognosis of resectable colorectal liver metastases (CRLM) was improved in the recent years with the consideration of chemotherapy and surgical resection as part of the multidisciplinary management of the disease; the current 5-year survival rates after resection of liver metastases are 25% to 40%. Resectable synchronous or metachronous liver metastases should be treated with perioperative chemotherapy based on three months of FOLFOX4 (5-fluorouracil [5FU], folinic acid [LV], and oxaliplatin) chemotherapy before surgery and three months after surgery. In the case of primary surgery, pseudo-adjuvant chemotherapy for 6 months, based on 5FU/LV, FOLFOX4, XELOX (capecitabine and oxaliplatin) or FOLFIRI (5FU/LV and irinotecan), should be indicated. In potentially resectable disease, primary chemotherapy based on more intensive regimens such as FOLFIRINOX (5FU/LV, irinotecan and oxaliplatin) should be considered to enhance the chance of cure. The palliative chemotherapy based on FOLFIRI, or FOLFOX4/XELOX with or without targeted therapies, is the mainstay treatment of unresectable disease. This review would provide additional insight into the problem of optimal integration of chemotherapy and surgery in the management of CRLM. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Malaysia | 1 | 1% |
| India | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Egypt | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 87 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 13% |
| Researcher | 11 | 12% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Postgraduate | 10 | 11% |
| Student > Bachelor | 8 | 9% |
| Other | 25 | 27% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 49% |
| Agricultural and Biological Sciences | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Nursing and Health Professions | 4 | 4% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 9 | 10% |
| Unknown | 21 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2011.
All research outputs
#18,301,870
of 22,659,164 outputs
Outputs from World Journal of Surgical Oncology
#1,025
of 2,038 outputs
Outputs of similar age
#195,458
of 239,474 outputs
Outputs of similar age from World Journal of Surgical Oncology
#29
of 49 outputs
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