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The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival

Overview of attention for article published in Cell, August 2018
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  • Good Attention Score compared to outputs of the same age (65th percentile)

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Title
The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival
Published in
Cell, August 2018
DOI 10.1016/j.cell.2018.07.046
Pubmed ID
Authors

Celine I. Maeder, Jae-Ick Kim, Xing Liang, Konstantin Kaganovsky, Ao Shen, Qin Li, Zhaoyu Li, Sui Wang, X.Z. Shawn Xu, Jin Billy Li, Yang Kevin Xiang, Jun B. Ding, Kang Shen

Abstract

Synaptic vesicle and active zone proteins are required for synaptogenesis. The molecular mechanisms for coordinated synthesis of these proteins are not understood. Using forward genetic screens, we identified the conserved THO nuclear export complex (THOC) as an important regulator of presynapse development in C. elegans dopaminergic neurons. In THOC mutants, synaptic messenger RNAs are retained in the nucleus, resulting in dramatic decrease of synaptic protein expression, near complete loss of synapses, and compromised dopamine function. CRE binding protein (CREB) interacts with THOC to mark synaptic transcripts for efficient nuclear export. Deletion of Thoc5, a THOC subunit, in mouse dopaminergic neurons causes severe defects in synapse maintenance and subsequent neuronal death in the substantia nigra compacta. These cellular defects lead to abrogated dopamine release, ataxia, and animal death. Together, our results argue that nuclear export mechanisms can select specific mRNAs and be a rate-limiting step for neuronal differentiation and survival.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 116 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 23%
Researcher 20 17%
Student > Doctoral Student 11 9%
Student > Master 9 8%
Student > Postgraduate 8 7%
Other 24 21%
Unknown 17 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 24%
Neuroscience 28 24%
Agricultural and Biological Sciences 20 17%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Nursing and Health Professions 4 3%
Other 10 9%
Unknown 22 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2021.
All research outputs
#7,209,370
of 25,385,509 outputs
Outputs from Cell
#11,862
of 17,170 outputs
Outputs of similar age
#116,987
of 342,525 outputs
Outputs of similar age from Cell
#158
of 172 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 17,170 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,525 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 172 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.