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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), August 2018
|
| DOI | 10.1016/j.chom.2018.07.018 |
| Pubmed ID | |
| Authors |
Jing Jin, Jesús G. Galaz-Montoya, Michael B. Sherman, Stella Y. Sun, Cynthia S. Goldsmith, Eileen T. O'Toole, Larry Ackerman, Lars-Anders Carlson, Scott C. Weaver, Wah Chiu, Graham Simmons |
| Abstract |
Neutralizing antibodies (NAbs) are traditionally thought to inhibit virus infection by preventing virion entry into target cells. In addition, antibodies can engage Fc receptors (FcRs) on immune cells to activate antiviral responses. We describe a mechanism by which NAbs inhibit chikungunya virus (CHIKV), the most common alphavirus infecting humans, by preventing virus budding from infected human cells and activating IgG-specific Fcγ receptors. NAbs bind to CHIKV glycoproteins on the infected cell surface and induce glycoprotein coalescence, preventing budding of nascent virions and leaving structurally heterogeneous nucleocapsids arrested in the cytosol. Furthermore, NAbs induce clustering of CHIKV replication spherules at sites of budding blockage. Functionally, these densely packed glycoprotein-NAb complexes on infected cells activate Fcγ receptors, inducing a strong, antibody-dependent, cell-mediated cytotoxicity response from immune effector cells. Our findings describe a triply functional antiviral pathway for NAbs that might be broadly applicable across virus-host systems, suggesting avenues for therapeutic innovation through antibody design. |
X Demographics
The data shown below were collected from the profiles of 37 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 22% |
| United Kingdom | 3 | 8% |
| India | 2 | 5% |
| Chile | 2 | 5% |
| Colombia | 1 | 3% |
| Switzerland | 1 | 3% |
| Russia | 1 | 3% |
| Israel | 1 | 3% |
| Nepal | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 15 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 49% |
| Scientists | 15 | 41% |
| Science communicators (journalists, bloggers, editors) | 3 | 8% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 23% |
| Researcher | 15 | 17% |
| Student > Bachelor | 13 | 14% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 6 | 7% |
| Other | 8 | 9% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 24 | 27% |
| Biochemistry, Genetics and Molecular Biology | 20 | 22% |
| Agricultural and Biological Sciences | 15 | 17% |
| Arts and Humanities | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 9 | 10% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2023.
All research outputs
#1,044,725
of 25,385,509 outputs
Outputs from Cell Host & Microbe (Science Direct)
#705
of 2,627 outputs
Outputs of similar age
#22,130
of 342,525 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#14
of 49 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,627 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,525 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.