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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
|
|---|---|
| Published in |
Journal of Controlled Release, November 2011
|
| DOI | 10.1016/j.jconrel.2011.11.014 |
| Pubmed ID | |
| Authors |
Claudia Scholz, Ernst Wagner |
| Abstract |
Gene therapy offers great opportunities for the treatment of severe diseases including cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become a research field of increasing interest. Studies on the delivery of plasmid DNA (pDNA) have brought up a variety of gene delivery vehicles. The more recently emerged gene silencing strategy by the intracellular delivery of small interfering RNA (siRNA) takes benefit from existing expertise in pDNA transfer. Despite common properties however, delivery of siRNA also faces distinct challenges due to apparent differences in size, stability of the formed nucleic acid complexes, the location and mechanism of action. This review emphasizes the common aspects and main differences between pDNA and siRNA delivery, taking into consideration a wide spectrum of polymer-based, lipidic and peptide carriers. Challenges and opportunities which result from these differences as well as the recent progress made in the optimization of carrier design are presented. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 318 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Spain | 2 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Unknown | 308 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 103 | 32% |
| Student > Master | 44 | 14% |
| Researcher | 38 | 12% |
| Student > Bachelor | 26 | 8% |
| Student > Doctoral Student | 25 | 8% |
| Other | 36 | 11% |
| Unknown | 46 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 18% |
| Chemistry | 53 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 34 | 11% |
| Biochemistry, Genetics and Molecular Biology | 29 | 9% |
| Medicine and Dentistry | 28 | 9% |
| Other | 52 | 16% |
| Unknown | 65 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2022.
All research outputs
#5,165,888
of 25,374,647 outputs
Outputs from Journal of Controlled Release
#1,802
of 9,727 outputs
Outputs of similar age
#39,691
of 245,312 outputs
Outputs of similar age from Journal of Controlled Release
#21
of 90 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,727 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,312 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.