| Title |
Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2011
|
| DOI | 10.1007/s00018-010-0613-2 |
| Pubmed ID | |
| Authors |
Takehiko Kobayashi |
| Abstract |
The genes encoding ribosomal RNA (rRNA) are the most abundant genes in the eukaryotic genome. They reside in tandem repetitive clusters, in some cases totaling hundreds of copies. Due to their repetitive structure and highly active transcription, the rRNA gene repeats are some of the most fragile sites in the chromosome. A unique gene amplification system compensates for loss of copies, thus maintaining copy number, albeit with some fluctuations. The unusual nature of rRNA gene repeats affects cellular functions such as senescence. In addition, we recently found that the repeat number determines sensitivity to DNA damage. In this review, I would like to introduce a new aspect of the rRNA gene repeat (called rDNA) as a center of maintenance of genome integrity and discuss its contribution to evolution. |
Mendeley readers
The data shown below were compiled from readership statistics for 285 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Netherlands | 2 | <1% |
| Spain | 2 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Israel | 1 | <1% |
| Brazil | 1 | <1% |
| Belgium | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 271 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 23% |
| Researcher | 57 | 20% |
| Student > Master | 31 | 11% |
| Student > Bachelor | 29 | 10% |
| Student > Doctoral Student | 18 | 6% |
| Other | 36 | 13% |
| Unknown | 49 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 117 | 41% |
| Biochemistry, Genetics and Molecular Biology | 86 | 30% |
| Immunology and Microbiology | 4 | 1% |
| Environmental Science | 4 | 1% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 1% |
| Other | 16 | 6% |
| Unknown | 55 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2011.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
of 4,151 outputs
Outputs of similar age
#144,845
of 185,154 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#16
of 20 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,154 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.