| Title |
Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene
|
|---|---|
| Published in |
Archives of Virology, May 2015
|
| DOI | 10.1007/s00705-015-2457-4 |
| Pubmed ID | |
| Authors |
Tadaaki Watanabe, Emi Inoue, Hiroshi Mori, Yoshiaki Osawa, Katsunori Okazaki |
| Abstract |
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), to which animals are most susceptible at 4-8 years of age. In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. Such a deficient enzyme may exhibit a dominant negative effect on the wild-type RT and cause insufficient viral replication, resulting in delayed tumor development in this cow. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 3 | 25% |
| Student > Bachelor | 2 | 17% |
| Student > Ph. D. Student | 2 | 17% |
| Student > Master | 2 | 17% |
| Professor | 1 | 8% |
| Other | 2 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 42% |
| Medicine and Dentistry | 2 | 17% |
| Immunology and Microbiology | 2 | 17% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Veterinary Science and Veterinary Medicine | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 1 | 8% |