You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
|
|---|---|
| Published in |
Cell Stem Cell, July 2010
|
| DOI | 10.1016/j.stem.2010.06.014 |
| Pubmed ID | |
| Authors |
Mary Mohrin, Emer Bourke, David Alexander, Matthew R. Warr, Keegan Barry-Holson, Michelle M. Le Beau, Ciaran G. Morrison, Emmanuelle Passegué |
| Abstract |
Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes endogenous stress caused by cellular respiration and DNA replication. We demonstrate that HSC quiescence can also have detrimental effects. We found that HSCs have unique cell-intrinsic mechanisms ensuring their survival in response to ionizing irradiation (IR), which include enhanced prosurvival gene expression and strong activation of p53-mediated DNA damage response. We show that quiescent and proliferating HSCs are equally radioprotected but use different types of DNA repair mechanisms. We describe how nonhomologous end joining (NHEJ)-mediated DNA repair in quiescent HSCs is associated with acquisition of genomic rearrangements, which can persist in vivo and contribute to hematopoietic abnormalities. Our results demonstrate that quiescence is a double-edged sword that renders HSCs intrinsically vulnerable to mutagenesis following DNA damage. |
Mendeley readers
The data shown below were compiled from readership statistics for 496 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| Finland | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 484 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 134 | 27% |
| Researcher | 115 | 23% |
| Student > Master | 43 | 9% |
| Professor > Associate Professor | 31 | 6% |
| Student > Bachelor | 27 | 5% |
| Other | 69 | 14% |
| Unknown | 77 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 198 | 40% |
| Biochemistry, Genetics and Molecular Biology | 134 | 27% |
| Medicine and Dentistry | 41 | 8% |
| Immunology and Microbiology | 14 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 1% |
| Other | 23 | 5% |
| Unknown | 81 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2023.
All research outputs
#1,424,952
of 25,374,917 outputs
Outputs from Cell Stem Cell
#932
of 2,823 outputs
Outputs of similar age
#4,519
of 104,614 outputs
Outputs of similar age from Cell Stem Cell
#1
of 41 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.