| Title |
The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2015
|
| DOI | 10.1007/s00018-015-2056-2 |
| Pubmed ID | |
| Authors |
Eszter Baricza, Viola Tamási, Nikolett Marton, Edit I. Buzás, György Nagy |
| Abstract |
The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor, which plays an essential role in the xenobiotic metabolism in a wide variety of cells. The AHR gene is evolutionarily conserved and it has a central role not only in the differentiation and maturation of many tissues, but also in the toxicological metabolism of the cell by the activation of metabolizing enzymes. Several lines of evidence support that both AHR agonists and antagonists have profound immunological effects; and recently, the AHR has been implicated in antibacterial host defense. According to recent studies, the AHR is essential for the differentiation and activation of T helper 17 (Th17) cells. It is well known that Th17 cells have a central role in the development of inflammation, which is crucial in the defense against pathogens. In addition, Th17 cells play a major role in the pathogenesis of several autoimmune diseases such as rheumatoid arthritis. Therefore, the AHR may provide connection between the environmental chemicals, the immune regulation, and autoimmunity. In the present review, we summarize the role of the AHR in the Th17 cell functions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Unknown | 71 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 19% |
| Researcher | 14 | 19% |
| Student > Bachelor | 7 | 10% |
| Student > Master | 6 | 8% |
| Student > Postgraduate | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 18 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 14 | 19% |
| Agricultural and Biological Sciences | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Medicine and Dentistry | 6 | 8% |
| Unspecified | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 20 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2016.
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#21,141,111
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Outputs from Cellular and Molecular Life Sciences
#3,769
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#240,963
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Outputs of similar age from Cellular and Molecular Life Sciences
#49
of 54 outputs
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