| Title |
The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model
|
|---|---|
| Published in |
Journal of Youth and Adolescence, October 2015
|
| DOI | 10.1007/s10964-015-0378-x |
| Pubmed ID | |
| Authors |
Leilei Zhang, Zhi Li, Jie Chen, Xinying Li, Jianxin Zhang, Jay Belsky |
| Abstract |
Although depressive symptoms are common during adolescence, little research has examined gene-environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene-environment interaction from a developmental perspective. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| Unknown | 81 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 26% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Bachelor | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Student > Postgraduate | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 21 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 36 | 44% |
| Medicine and Dentistry | 6 | 7% |
| Social Sciences | 5 | 6% |
| Neuroscience | 3 | 4% |
| Engineering | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 25 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2015.
All research outputs
#16,223,992
of 23,906,448 outputs
Outputs from Journal of Youth and Adolescence
#1,342
of 1,813 outputs
Outputs of similar age
#171,025
of 288,407 outputs
Outputs of similar age from Journal of Youth and Adolescence
#14
of 20 outputs
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