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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Paternal calorie restriction prior to conception alters anxiety-like behavior of the adult rat progeny
|
|---|---|
| Published in |
Psychoneuroendocrinology, October 2015
|
| DOI | 10.1016/j.psyneuen.2015.10.020 |
| Pubmed ID | |
| Authors |
Antonina Govic, Jim Penman, Amanda H. Tammer, Antonio G. Paolini |
| Abstract |
The maternal environment influences a broad range of phenotypic outcomes for offspring, with anxiety-like behavior being particularly susceptible to maternal environmental perturbations. Much less is known regarding paternal environmental influences. To investigate this, adult male rats were exposed to 25% calorie restriction (CR) or glucocorticoid elevation (CORT; 200μg/ml of corticosterone in drinking water) for ∼6 weeks prior to breeding. Elevated plus maze (EPM), open field (OF), predator odor (cat urine), and acoustic startle/pre-pulse inhibition (AS/PPI) were characterised in the adult male offspring. Plasma concentrations of corticotrophin-releasing hormone (CRF), adrenocorticotropin hormone (ACTH), and serum lepin were characterised in both sires and offspring. Maternal care received by litters was additionally observed. Expectedly, CR and CORT treatment attenuated weight gain, whilst only CR induced anxiolytic behavior in the EPM. The adult offspring sired by CR males also demonstrated a reduction in weight gain, food intake and serum leptin levels when compared to controls. Moreover, CR offspring demonstrated an anxiolytic-like profile in the EPM and OF, enhanced habituation to the AS pulse, reduced PPI, but no alteration to predator odor induced defensiveness compared to control. CORT offspring failed to demonstrate any behavioral differences from controls, however, exhibited a trend towards reduced ACTH and leptin concentration. Collectively, the results indicate that a reduction in calories in males prior to conception can affect the behavior of adult offspring. The phenotypic transmission of CR experiences from fathers to the progeny could potentially be mediated epigenetically. The role of glucocorticoid elevation and maternal care are also discussed. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| India | 1 | 13% |
| Germany | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 38% |
| Practitioners (doctors, other healthcare professionals) | 3 | 38% |
| Scientists | 1 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Student > Bachelor | 9 | 11% |
| Student > Master | 9 | 11% |
| Researcher | 8 | 10% |
| Student > Postgraduate | 5 | 6% |
| Other | 10 | 12% |
| Unknown | 25 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 16 | 20% |
| Agricultural and Biological Sciences | 12 | 15% |
| Neuroscience | 7 | 9% |
| Medicine and Dentistry | 5 | 6% |
| Nursing and Health Professions | 3 | 4% |
| Other | 10 | 12% |
| Unknown | 28 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#2,119,830
of 25,374,647 outputs
Outputs from Psychoneuroendocrinology
#609
of 3,904 outputs
Outputs of similar age
#29,953
of 295,360 outputs
Outputs of similar age from Psychoneuroendocrinology
#19
of 87 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.