| Title |
A randomized controlled trial of cognitive-behavioral stress management in breast cancer: survival and recurrence at 11-year follow-up
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, October 2015
|
| DOI | 10.1007/s10549-015-3626-6 |
| Pubmed ID | |
| Authors |
Jamie M. Stagl, Suzanne C. Lechner, Charles S. Carver, Laura C. Bouchard, Lisa M. Gudenkauf, Devika R. Jutagir, Alain Diaz, Qilu Yu, Bonnie B. Blomberg, Gail Ironson, Stefan Glück, Michael H. Antoni |
| Abstract |
Non-metastatic breast cancer patients often experience psychological distress which may influence disease progression and survival. Cognitive-behavioral stress management (CBSM) improves psychological adaptation and lowers distress during breast cancer treatment and long-term follow-ups. We examined whether breast cancer patients randomized to CBSM had improved survival and recurrence 8-15 years post-enrollment. From 1998 to 2005, women (N = 240) 2-10 weeks post-surgery for non-metastatic Stage 0-IIIb breast cancer were randomized to a 10-week, group-based CBSM intervention (n = 120) or a 1-day psychoeducational seminar control (n = 120). In 2013, 8-15 years post-study enrollment (11-year median), recurrence and survival data were collected. Cox Proportional Hazards Models and Weibull Accelerated Failure Time tests were used to assess group differences in all-cause mortality, breast cancer-specific mortality, and disease-free interval, controlling for biomedical confounders. Relative to the control, the CBSM group was found to have a reduced risk of all-cause mortality (HR = 0.21; 95 % CI [0.05, 0.93]; p = .040). Restricting analyses to women with invasive disease revealed significant effects of CBSM on breast cancer-related mortality (p = .006) and disease-free interval (p = .011). CBSM intervention delivered post-surgery may provide long-term clinical benefit for non-metastatic breast cancer patients in addition to previously established psychological benefits. Results should be interpreted with caution; however, the findings contribute to the limited evidence regarding physical benefits of psychosocial intervention post-surgery for non-metastatic breast cancer. Additional research is necessary to confirm these results and investigate potential explanatory mechanisms, including physiological pathways, health behaviors, and treatment adherence changes. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 191 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 30 | 16% |
| Student > Bachelor | 23 | 12% |
| Student > Ph. D. Student | 19 | 10% |
| Other | 14 | 7% |
| Researcher | 14 | 7% |
| Other | 35 | 18% |
| Unknown | 56 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 52 | 27% |
| Medicine and Dentistry | 31 | 16% |
| Nursing and Health Professions | 21 | 11% |
| Neuroscience | 6 | 3% |
| Agricultural and Biological Sciences | 5 | 3% |
| Other | 14 | 7% |
| Unknown | 62 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 123. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2020.
All research outputs
#295,849
of 23,340,595 outputs
Outputs from Breast Cancer Research and Treatment
#32
of 4,714 outputs
Outputs of similar age
#4,602
of 285,912 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#2
of 77 outputs
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