| Chapter title |
Immunomodulatory Role of Vitamin D: A Review
|
|---|---|
| Chapter number | 246 |
| Book title |
Current Trends in Immunity and Respiratory Infections
|
| Published in |
Advances in experimental medicine and biology, August 2018
|
| DOI | 10.1007/5584_2018_246 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-001634-0, 978-3-03-001635-7
|
| Authors |
Skrobot, Agnieszka, Demkow, Urszula, Wachowska, Małgorzata, Agnieszka Skrobot, Urszula Demkow, Małgorzata Wachowska |
| Abstract |
Vitamin D is well known for its classical hormonal action related to the maintenance of mineral and skeletal homeostasis. However, the discovery that vitamin D receptor (VDR) is expressed in most non-skeletal tissues points to its broad role in the human organism. Current literature emphasizes a multidirectional role of vitamin D, with a special focus on its immunomodulatory properties. As VDR and the enzyme 1-α-hydroxylase are expressed in most immune cells, vitamin D modulates the phagocytic activity of macrophages and natural killer cells. In addition, it induces the microbicidal activity of phagocytes. In contrast, vitamin D suppresses differentiation and maturation of antigen-presenting dendritic cells and B lymphocytes, and it inhibits proliferation of Th1 and Th17 cells. In this review we aimed to describe the current scientific discoveries on the role of vitamin D as immunomodulator. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 8 | 27% |
| United Kingdom | 3 | 10% |
| United States | 1 | 3% |
| Argentina | 1 | 3% |
| Bosnia and Herzegovina | 1 | 3% |
| Mexico | 1 | 3% |
| Unknown | 15 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 87% |
| Practitioners (doctors, other healthcare professionals) | 3 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 18% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Doctoral Student | 6 | 8% |
| Lecturer | 3 | 4% |
| Student > Master | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 36 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 16% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Immunology and Microbiology | 4 | 5% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 41 | 52% |