| Title |
Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, August 2018
|
| DOI | 10.1007/s12031-018-1155-6 |
| Pubmed ID | |
| Authors |
Jia-rui Wu, Qing-zhang Tuo, Peng Lei |
| Abstract |
Ferroptosis is a recently defined form of cell death with the involvement of iron and reactive oxygen species (ROS), which is distinct from apoptosis, autophagy and other forms of cell death. Emerging evidence suggested that iron accumulation and lipid peroxidation can be discovered in various neurological diseases, accompanied with reduction of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In addition, ferroptotic inhibitors have been shown to protect neurons, and recover the cognitive function in disease animal models. This review summarizes the mechanisms underlying ferroptosis and reviews the contributions of ferroptosis in neurodegenerative diseases (i.e. Alzheimer's disease and Parkinson's disease), traumatic brain injury, as well as hemorrhagic and ischemic stroke, to provide the current understanding of this novel form of cell death in neurological disorders. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 18% |
| Researcher | 16 | 14% |
| Student > Bachelor | 16 | 14% |
| Student > Master | 12 | 11% |
| Student > Doctoral Student | 8 | 7% |
| Other | 14 | 12% |
| Unknown | 27 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 24% |
| Neuroscience | 19 | 17% |
| Medicine and Dentistry | 13 | 12% |
| Agricultural and Biological Sciences | 6 | 5% |
| Immunology and Microbiology | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 31 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2022.
All research outputs
#2,125,430
of 25,385,509 outputs
Outputs from Journal of Molecular Neuroscience
#23
of 1,643 outputs
Outputs of similar age
#42,761
of 342,957 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#1
of 46 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.