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Endocytosis regulates TDP-43 toxicity and turnover

Overview of attention for article published in Nature Communications, December 2017
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Title
Endocytosis regulates TDP-43 toxicity and turnover
Published in
Nature Communications, December 2017
DOI 10.1038/s41467-017-02017-x
Pubmed ID
Authors

Guangbo Liu, Alyssa N. Coyne, Fen Pei, Spencer Vaughan, Matthew Chaung, Daniela C. Zarnescu, J. Ross Buchan

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear mechanisms. Here, we demonstrate that TDP-43 turnover and toxicity depend in part upon the endocytosis pathway. TDP-43 inhibits endocytosis, and co-localizes strongly with endocytic proteins, including in ALS patient tissue. Impairing endocytosis increases TDP-43 toxicity, aggregation, and protein levels, whereas enhancing endocytosis reverses these phenotypes. Locomotor dysfunction in a TDP-43 ALS fly model is also exacerbated and suppressed by impairment and enhancement of endocytic function, respectively. Thus, endocytosis dysfunction may be an underlying cause of ALS pathology.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 137 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 26%
Student > Master 17 12%
Student > Bachelor 16 12%
Researcher 13 9%
Student > Doctoral Student 10 7%
Other 12 9%
Unknown 33 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 28%
Neuroscience 32 23%
Agricultural and Biological Sciences 14 10%
Medicine and Dentistry 5 4%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 6 4%
Unknown 37 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2018.
All research outputs
#15,866,607
of 23,577,654 outputs
Outputs from Nature Communications
#43,949
of 49,108 outputs
Outputs of similar age
#269,770
of 441,825 outputs
Outputs of similar age from Nature Communications
#1,272
of 1,436 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 49,108 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,825 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,436 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.