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X Demographics
Mendeley readers
Attention Score in Context
| Title |
APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions
|
|---|---|
| Published in |
Cell Reports, October 2015
|
| DOI | 10.1016/j.celrep.2015.09.077 |
| Pubmed ID | |
| Authors |
Marat D. Kazanov, Steven A. Roberts, Paz Polak, John Stamatoyannopoulos, Leszek J. Klimczak, Dmitry A. Gordenin, Shamil R. Sunyaev |
| Abstract |
An antiviral component of the human innate immune system-the APOBEC cytidine deaminases-was recently identified as a prominent source of mutations in cancers. Here, we investigated the distribution of APOBEC-induced mutations across the genomes of 119 breast and 24 lung cancer samples. While the rate of most mutations is known to be elevated in late-replicating regions that are characterized by reduced chromatin accessibility and low gene density, we observed a marked enrichment of APOBEC mutations in early-replicating regions. This unusual mutagenesis profile may be associated with a higher propensity to form single-strand DNA substrates for APOBEC enzymes in early-replicating regions and should be accounted for in statistical analyses of cancer genome mutation catalogs aimed at understanding the mechanisms of carcinogenesis as well as highlighting genes that are significantly mutated in cancer. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| France | 1 | 14% |
| South Africa | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Scientists | 3 | 43% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 119 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 28% |
| Researcher | 31 | 26% |
| Student > Bachelor | 11 | 9% |
| Student > Master | 8 | 7% |
| Professor > Associate Professor | 5 | 4% |
| Other | 12 | 10% |
| Unknown | 19 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 36% |
| Agricultural and Biological Sciences | 40 | 34% |
| Medicine and Dentistry | 7 | 6% |
| Mathematics | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 5 | 4% |
| Unknown | 20 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2015.
All research outputs
#7,724,982
of 25,402,528 outputs
Outputs from Cell Reports
#9,838
of 12,994 outputs
Outputs of similar age
#89,371
of 295,465 outputs
Outputs of similar age from Cell Reports
#160
of 251 outputs
Altmetric has tracked 25,402,528 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 12,994 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,465 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 251 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.