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Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves

Overview of attention for article published in Nature Communications, November 2015
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)

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Title
Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves
Published in
Nature Communications, November 2015
DOI 10.1038/ncomms9686
Pubmed ID
Authors

David J. Collins, Belinda Morahan, Jose Garcia-Bustos, Christian Doerig, Magdalena Plebanski, Adrian Neild

Abstract

In single-cell analysis, cellular activity and parameters are assayed on an individual, rather than population-average basis. Essential to observing the activity of these cells over time is the ability to trap, pattern and retain them, for which previous single-cell-patterning work has principally made use of mechanical methods. While successful as a long-term cell-patterning strategy, these devices remain essentially single use. Here we introduce a new method for the patterning of multiple spatially separated single particles and cells using high-frequency acoustic fields with one cell per acoustic well. We characterize and demonstrate patterning for both a range of particle sizes and the capture and patterning of cells, including human lymphocytes and red blood cells infected by the malarial parasite Plasmodium falciparum. This ability is made possible by a hitherto unexplored regime where the acoustic wavelength is on the same order as the cell dimensions.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 404 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
France 2 <1%
Japan 2 <1%
Ireland 1 <1%
United Kingdom 1 <1%
Germany 1 <1%
Finland 1 <1%
Taiwan 1 <1%
Unknown 392 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 120 30%
Researcher 45 11%
Student > Master 44 11%
Student > Bachelor 27 7%
Student > Doctoral Student 21 5%
Other 44 11%
Unknown 103 25%
Readers by discipline Count As %
Engineering 149 37%
Physics and Astronomy 32 8%
Agricultural and Biological Sciences 24 6%
Materials Science 21 5%
Chemistry 19 5%
Other 38 9%
Unknown 121 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2015.
All research outputs
#12,938,208
of 22,831,537 outputs
Outputs from Nature Communications
#37,988
of 47,018 outputs
Outputs of similar age
#126,993
of 285,068 outputs
Outputs of similar age from Nature Communications
#606
of 816 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 47,018 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,068 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 816 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.