| Title |
The role of surgery in the management of patients with diffuse low grade glioma
|
|---|---|
| Published in |
Journal of Neuro-Oncology, November 2015
|
| DOI | 10.1007/s11060-015-1867-1 |
| Pubmed ID | |
| Authors |
Manish K. Aghi, Brian V. Nahed, Andrew E. Sloan, Timothy C. Ryken, Steven N. Kalkanis, Jeffrey J. Olson |
| Abstract |
Should patients with imaging suggestive of low grade glioma (LGG) undergo observation versus treatment involving a surgical procedure? These recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). Surgical resection is recommended over observation to improve overall survival for patients with diffuse low-grade glioma (Level III) although observation has no negative impact on cognitive performance and quality of life (Level II). What is the impact of extent of resection on progression free survival (PFS) or overall survival (OS) in LGG patients? These recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). IMPACT OF EXTENT OF RESECTION ON PFS : LEVEL II : It is recommended that GTR or STR be accomplished instead of biopsy alone when safe and feasible so as to decrease the frequency of tumor progression recognizing that the rate of progression after GTR is fairly high. LEVEL III : Greater extent of resection can improve OS in LGG patients. What tools are available to increase extent of resection in LGG patients? These recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). INTRAOPERATIVE MRI DURING SURGERY : LEVEL III : The use of intraoperative MRI should be considered as a method of increasing the extent of resection of LGGs. What is the impact of surgical resection on seizure control and accuracy of pathology in low grade glioma patients? These recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). SURGICAL RESECTION AND SEIZURE CONTROL : LEVEL III : After taking into account the patient's clinical status and tumor location, gross total resection is recommended for patients with diffuse LGG as a way to achieve more favorable seizure control. LEVEL III : Taking into account the patient's clinical status and tumor location, surgical resection should be carried out to maximize the chance of accurate diagnosis. What tools can improve the safety of surgery for LGGs in eloquent locations? These recommendations apply to adults with imaging suggestive of a WHO grade 2 glioma (oligodendroglioma, astrocytoma, or oligo-astrocytoma). PREOPERATIVE IMAGING : LEVEL III : It is recommended that preoperative functional MRI and diffusion tensor imaging be utilized in the appropriate clinical setting to improve functional outcome after surgery for LGG. LEVEL III : Intraoperative mapping is recommended for patients with diffuse LGGs in eloquent locations compared to patients with non-eloquently located diffuse LGGs as a way of preserving function. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 145 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 23 | 16% |
| Student > Postgraduate | 14 | 10% |
| Student > Doctoral Student | 14 | 10% |
| Student > Ph. D. Student | 13 | 9% |
| Student > Master | 13 | 9% |
| Other | 39 | 27% |
| Unknown | 29 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 43% |
| Neuroscience | 23 | 16% |
| Biochemistry, Genetics and Molecular Biology | 5 | 3% |
| Physics and Astronomy | 2 | 1% |
| Psychology | 2 | 1% |
| Other | 11 | 8% |
| Unknown | 40 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2018.
All research outputs
#6,426,442
of 22,832,057 outputs
Outputs from Journal of Neuro-Oncology
#807
of 2,970 outputs
Outputs of similar age
#81,881
of 285,121 outputs
Outputs of similar age from Journal of Neuro-Oncology
#12
of 68 outputs
Altmetric has tracked 22,832,057 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,970 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,121 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.