| Title |
Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs
|
|---|---|
| Published in |
Journal of Neuro-Oncology, November 2011
|
| DOI | 10.1007/s11060-011-0763-6 |
| Pubmed ID | |
| Authors |
Yuejun Fu, Na An, Ke Li, Yali Zheng, Aihua Liang |
| Abstract |
Development of glioma-specific nanoparticles has been an area of intense research over the past several years. Iron oxide, multifunctional superparamagnetic, and NaYF(4):Yb,rare-earth upconversion nanoparticles, conjugated with chlorotoxin (CTX, a key toxin in scorpion venom which has been shown to bind specifically to glioma cell surface as a specific chloride channel and matrix metalloproteinase-2 blocker), exhibit high affinity for glioma and direct tumor visualization. We review the latest improvements of CTX-modified nanoparticle platforms which might enable development of more effective therapeutic agents in clinical treatment of glioma. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 5% |
| Italy | 1 | 3% |
| Egypt | 1 | 3% |
| Unknown | 35 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 36% |
| Researcher | 8 | 21% |
| Student > Master | 5 | 13% |
| Student > Doctoral Student | 2 | 5% |
| Student > Bachelor | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 28% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 18% |
| Biochemistry, Genetics and Molecular Biology | 6 | 15% |
| Medicine and Dentistry | 4 | 10% |
| Chemistry | 3 | 8% |
| Other | 4 | 10% |
| Unknown | 4 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2011.
All research outputs
#18,301,870
of 22,659,164 outputs
Outputs from Journal of Neuro-Oncology
#2,223
of 2,954 outputs
Outputs of similar age
#195,452
of 239,459 outputs
Outputs of similar age from Journal of Neuro-Oncology
#13
of 17 outputs
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.