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Basomedial amygdala mediates top-down control of anxiety and fear

Overview of attention for article published in Nature, November 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Average Attention Score compared to outputs of the same age and source

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982 Mendeley
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Title
Basomedial amygdala mediates top-down control of anxiety and fear
Published in
Nature, November 2015
DOI 10.1038/nature15698
Pubmed ID
Authors

Avishek Adhikari, Talia N. Lerner, Joel Finkelstein, Sally Pak, Joshua H. Jennings, Thomas J. Davidson, Emily Ferenczi, Lisa A. Gunaydin, Julie J. Mirzabekov, Li Ye, Sung-Yon Kim, Anna Lei, Karl Deisseroth

Abstract

Anxiety-related conditions are among the most difficult neuropsychiatric diseases to treat pharmacologically, but respond to cognitive therapies. There has therefore been interest in identifying relevant top-down pathways from cognitive control regions in medial prefrontal cortex (mPFC). Identification of such pathways could contribute to our understanding of the cognitive regulation of affect, and provide pathways for intervention. Previous studies have suggested that dorsal and ventral mPFC subregions exert opposing effects on fear, as do subregions of other structures. However, precise causal targets for top-down connections among these diverse possibilities have not been established. Here we show that the basomedial amygdala (BMA) represents the major target of ventral mPFC in amygdala in mice. Moreover, BMA neurons differentiate safe and aversive environments, and BMA activation decreases fear-related freezing and high-anxiety states. Lastly, we show that the ventral mPFC-BMA projection implements top-down control of anxiety state and learned freezing, both at baseline and in stress-induced anxiety, defining a broadly relevant new top-down behavioural regulation pathway.

X Demographics

X Demographics

The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 982 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 1%
France 5 <1%
Germany 4 <1%
Japan 4 <1%
United Kingdom 4 <1%
Switzerland 2 <1%
Austria 2 <1%
Netherlands 2 <1%
Spain 2 <1%
Other 6 <1%
Unknown 939 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 266 27%
Researcher 176 18%
Student > Master 102 10%
Student > Bachelor 101 10%
Student > Doctoral Student 60 6%
Other 152 15%
Unknown 125 13%
Readers by discipline Count As %
Neuroscience 361 37%
Agricultural and Biological Sciences 205 21%
Psychology 88 9%
Medicine and Dentistry 59 6%
Biochemistry, Genetics and Molecular Biology 35 4%
Other 69 7%
Unknown 165 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#684,293
of 25,550,333 outputs
Outputs from Nature
#26,675
of 98,234 outputs
Outputs of similar age
#10,358
of 297,215 outputs
Outputs of similar age from Nature
#584
of 1,174 outputs
Altmetric has tracked 25,550,333 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,234 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,215 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,174 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.