| Title |
Telomere homeostasis in mammalian germ cells: a review
|
|---|---|
| Published in |
Chromosoma, November 2015
|
| DOI | 10.1007/s00412-015-0555-4 |
| Pubmed ID | |
| Authors |
Rita Reig-Viader, Montserrat Garcia-Caldés, Aurora Ruiz-Herrera |
| Abstract |
Telomeres protect against genome instability and participate in chromosomal movements during gametogenesis, especially in meiosis. Thus, maintaining telomere structure and telomeric length is essential to both cell integrity and the production of germ cells. As a result, alteration of telomere homeostasis in the germ line may result in the generation of aneuploid gametes or gametogenesis disruption, triggering fertility problems. In this work, we provide an overview on fundamental aspects of the literature regarding the organization of telomeres in mammalian germ cells, paying special attention to telomere structure and function, as well as the maintenance of telomeric length during gametogenesis. Moreover, we discuss the different roles recently described for telomerase and TERRA in maintaining telomere functionality. Finally, we review how new findings in the field of reproductive biology underscore the role of telomere homeostasis as a potential biomarker for infertility. Overall, we anticipate that the study of telomere stability and equilibrium will contribute to improve diagnoses of patients; assess the risk of infertility in the offspring; and in turn, find new treatments. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 85 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 20% |
| Student > Ph. D. Student | 13 | 15% |
| Student > Bachelor | 11 | 13% |
| Student > Master | 10 | 11% |
| Professor > Associate Professor | 7 | 8% |
| Other | 9 | 10% |
| Unknown | 20 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 31% |
| Agricultural and Biological Sciences | 20 | 23% |
| Medicine and Dentistry | 3 | 3% |
| Nursing and Health Professions | 3 | 3% |
| Neuroscience | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 25 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2015.
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#20,295,501
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Outputs from Chromosoma
#695
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Outputs of similar age
#238,941
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Outputs of similar age from Chromosoma
#16
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