Title |
A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers
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Published in |
Nature Communications, August 2018
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DOI | 10.1038/s41467-018-05624-4 |
Pubmed ID | |
Authors |
Jonathan D. Mosley, QiPing Feng, Quinn S. Wells, Sara L. Van Driest, Christian M. Shaffer, Todd L. Edwards, Lisa Bastarache, Wei-Qi Wei, Lea K. Davis, Catherine A. McCarty, Will Thompson, Christopher G. Chute, Gail P. Jarvik, Adam S. Gordon, Melody R. Palmer, David R. Crosslin, Eric B. Larson, David S. Carrell, Iftikhar J. Kullo, Jennifer A. Pacheco, Peggy L. Peissig, Murray H. Brilliant, James G. Linneman, Bahram Namjou, Marc S. Williams, Marylyn D. Ritchie, Kenneth M. Borthwick, Shefali S. Verma, Jason H. Karnes, Scott T. Weiss, Thomas J. Wang, C. Michael Stein, Josh C. Denny, Dan M. Roden |
Abstract |
Defining the full spectrum of human disease associated with a biomarker is necessary to advance the biomarker into clinical practice. We hypothesize that associating biomarker measurements with electronic health record (EHR) populations based on shared genetic architectures would establish the clinical epidemiology of the biomarker. We use Bayesian sparse linear mixed modeling to calculate SNP weightings for 53 biomarkers from the Atherosclerosis Risk in Communities study. We use the SNP weightings to computed predicted biomarker values in an EHR population and test associations with 1139 diagnoses. Here we report 116 associations meeting a Bonferroni level of significance. A false discovery rate (FDR)-based significance threshold reveals more known and undescribed associations across a broad range of biomarkers, including biometric measures, plasma proteins and metabolites, functional assays, and behaviors. We confirm an inverse association between LDL-cholesterol level and septicemia risk in an independent epidemiological cohort. This approach efficiently discovers biomarker-disease associations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 20% |
United States | 1 | 20% |
Canada | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 21% |
Student > Bachelor | 10 | 13% |
Researcher | 9 | 12% |
Student > Master | 7 | 9% |
Professor > Associate Professor | 5 | 7% |
Other | 8 | 11% |
Unknown | 21 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 26% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Agricultural and Biological Sciences | 5 | 7% |
Nursing and Health Professions | 5 | 7% |
Computer Science | 3 | 4% |
Other | 9 | 12% |
Unknown | 25 | 33% |