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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence
|
|---|---|
| Published in |
International Journal of Cancer, November 2015
|
| DOI | 10.1002/ijc.29914 |
| Pubmed ID | |
| Authors |
Julia Butt, Beatriz Romero-Hernández, Beatriz Pérez-Gómez, Martina Willhauck-Fleckenstein, Dana Holzinger, Vicente Martin, Victor Moreno, Cristina Linares, Trinidad Dierssen-Sotos, Aurelio Barricarte, Adonina Tardón, Jone M Altzibar, Eduardo Moreno-Osset, Francisco Franco, Rocío Olmedo Requena, José María Huerta, Angelika Michel, Tim Waterboer, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Annemarie Boleij, Silvia de Sanjosé, Rosa Del Campo, Harold Tjalsma, Nuria Aragonés, Michael Pawlita |
| Abstract |
The colonic opportunist Streptococcus gallolyticus subspecies gallolyticus (SGG) is potentially associated with colorectal cancer (CRC). Large-scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population-based multicase-control project (MCC-Spain). MCC-Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity-purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease-specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09-2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09-2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00-2.11) were significantly associated with CRC risk. The association was stronger for positivity to 2 or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04-3.56) and for double-positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49-8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 18% |
| Student > Ph. D. Student | 9 | 15% |
| Researcher | 9 | 15% |
| Student > Master | 5 | 8% |
| Professor | 3 | 5% |
| Other | 11 | 18% |
| Unknown | 13 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 20% |
| Medicine and Dentistry | 11 | 18% |
| Agricultural and Biological Sciences | 8 | 13% |
| Immunology and Microbiology | 5 | 8% |
| Chemistry | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 18 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2017.
All research outputs
#2,588,420
of 24,477,448 outputs
Outputs from International Journal of Cancer
#1,011
of 12,080 outputs
Outputs of similar age
#42,593
of 396,350 outputs
Outputs of similar age from International Journal of Cancer
#15
of 81 outputs
Altmetric has tracked 24,477,448 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,080 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,350 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.