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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas
|
|---|---|
| Published in |
Modern Pathology, August 2018
|
| DOI | 10.1038/s41379-018-0114-7 |
| Pubmed ID | |
| Authors |
Sandy Liu, Mithat Gӧnen, Zsofia K. Stadler, Martin R. Weiser, Jaclyn F. Hechtman, Efsevia Vakiani, Tao Wang, Monika Vyas, Upasana Joneja, Moataz Al-Bayati, Neil H. Segal, J. Joshua Smith, Sarah King, Shanna Guercio, Peter Ntiamoah, Arnold J. Markowitz, Liying Zhang, Andrea Cercek, Julio Garcia-Aguilar, Leonard B. Saltz, Luis A. Diaz, David S. Klimstra, Jinru Shia |
| Abstract |
Blockade of the interaction between PD-1 and its ligands PD-L1 has shown clinical efficacy across several tumor types, especially in mismatch-repair-deficient colorectal carcinoma. The aim of this study was to examine the pattern and cellular localization of PD-L1 expression in the different molecular subtypes of mismatch-repair-deficient colorectal cancers vs. their mismatch-repair-proficient counterparts. PD-L1/SATB2 double-antibody-immunohistochemistry was utilized to distinguish tumor cell from immune cell staining. We observed in our series of 129 colorectal adenocarcinomas that PD-L1 expression occurred primarily in tumor-associated-immune cells and most prominently at the tumor-stroma-interface of the invasive front. The level of invasive front immune cell staining was significantly higher in mismatch-repair-deficient tumors compared to mismatch-repair-proficient tumors (p < 0.001), but no difference was observed among the different subtypes of mismatch-repair-deficient tumors: Lynch syndrome-associated vs. MLH1-methylated vs. unexplained. While selected mismatch-repair-proficient tumors exhibited unusually high tumor-infiltrating-lymphocytes and had high level immune cell PD-L1 expression, a positive correlation between PD-L1 expression and high lymphocyte count was detected only in mismatch-repair-deficient tumors (r = 0.39, p < 0.001) and not in mismatch-repair-proficient tumors. Notably, true tumor cell PD-L1 expression in colorectal carcinoma was rare, present in only 3 of 129 tumors (2.3%): 2 MLH1-methylated and 1 mismatch-repair-proficient with high tumor-infiltrating-lymphocytes; and the staining in the tumor cells in all 3 was diffuse (>=50% of the tumor). These findings may serve to inform further efforts aiming to evaluate PD-L1 immunohistochemistry vis-à-vis molecular sub-classification as predictive biomarkers in the treatment of colorectal carcinoma. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 36% |
| Spain | 3 | 14% |
| Canada | 3 | 14% |
| Brazil | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 6 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 64% |
| Practitioners (doctors, other healthcare professionals) | 5 | 23% |
| Scientists | 3 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 14% |
| Other | 6 | 14% |
| Student > Bachelor | 6 | 14% |
| Student > Ph. D. Student | 5 | 11% |
| Researcher | 3 | 7% |
| Other | 6 | 14% |
| Unknown | 12 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 34% |
| Biochemistry, Genetics and Molecular Biology | 9 | 20% |
| Agricultural and Biological Sciences | 2 | 5% |
| Social Sciences | 2 | 5% |
| Unspecified | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 12 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2019.
All research outputs
#2,628,157
of 25,385,509 outputs
Outputs from Modern Pathology
#574
of 3,283 outputs
Outputs of similar age
#52,309
of 344,376 outputs
Outputs of similar age from Modern Pathology
#9
of 45 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,283 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,376 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.