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Attention Score in Context
| Title |
The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition
|
|---|---|
| Published in |
Biological Psychiatry, November 2015
|
| DOI | 10.1016/j.biopsych.2015.10.021 |
| Pubmed ID | |
| Authors |
Loyse Hippolyte, Anne M. Maillard, Borja Rodriguez-Herreros, Aurélie Pain, Sandra Martin-Brevet, Carina Ferrari, Philippe Conus, Aurélien Macé, Nouchine Hadjikhani, Andres Metspalu, Anu Reigo, Anneli Kolk, Katrin Männik, Mandy Barker, Bertrand Isidor, Cédric Le Caignec, Cyril Mignot, Laurence Schneider, Laurent Mottron, Boris Keren, Albert David, Martine Doco-Fenzy, Marion Gérard, Raphael Bernier, Robin P. Goin-Kochel, Ellen Hanson, LeeAnne Green Snyder, Simons Variation in Individuals Project Consortium 16p11.2 European Consortium, Franck Ramus, Jacques S. Beckmann, Bogdan Draganski, Alexandre Reymond, Sébastien Jacquemont |
| Abstract |
Deletions and duplications of the 16p11.2 BP4-BP5 locus are prevalent copy number variations (CNVs), highly associated with autism spectrum disorder and schizophrenia. Beyond language and global cognition, neuropsychological assessments of these two CNVs have not yet been reported. This study investigates the relationship between the number of genomic copies at the 16p11.2 locus and cognitive domains assessed in 62 deletion carriers, 44 duplication carriers, and 71 intrafamilial control subjects. IQ is decreased in deletion and duplication carriers, but we demonstrate contrasting cognitive profiles in these reciprocal CNVs. Deletion carriers present with severe impairments of phonology and of inhibition skills beyond what is expected for their IQ level. In contrast, for verbal memory and phonology, the data may suggest that duplication carriers outperform intrafamilial control subjects with the same IQ level. This finding is reminiscent of special isolated skills as well as contrasting language performance observed in autism spectrum disorder. Some domains, such as visuospatial and working memory, are unaffected by the 16p11.2 locus beyond the effect of decreased IQ. Neuroimaging analyses reveal that measures of inhibition covary with neuroanatomic structures previously identified as sensitive to 16p11.2 CNVs. The simultaneous study of reciprocal CNVs suggests that the 16p11.2 genomic locus modulates specific cognitive skills according to the number of genomic copies. Further research is warranted to replicate these findings and elucidate the molecular mechanisms modulating these cognitive performances. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 3 | 33% |
| Mexico | 2 | 22% |
| United States | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Scientists | 1 | 11% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 205 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 32 | 15% |
| Student > Ph. D. Student | 31 | 15% |
| Student > Bachelor | 22 | 11% |
| Researcher | 21 | 10% |
| Student > Doctoral Student | 14 | 7% |
| Other | 40 | 19% |
| Unknown | 49 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 44 | 21% |
| Neuroscience | 32 | 15% |
| Agricultural and Biological Sciences | 16 | 8% |
| Biochemistry, Genetics and Molecular Biology | 15 | 7% |
| Medicine and Dentistry | 15 | 7% |
| Other | 30 | 14% |
| Unknown | 57 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 66. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2022.
All research outputs
#643,989
of 25,374,917 outputs
Outputs from Biological Psychiatry
#432
of 6,597 outputs
Outputs of similar age
#9,568
of 294,330 outputs
Outputs of similar age from Biological Psychiatry
#18
of 85 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,597 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,330 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.