| Title |
Leaky Gut and Autoimmune Diseases
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, November 2011
|
| DOI | 10.1007/s12016-011-8291-x |
| Pubmed ID | |
| Authors |
Alessio Fasano |
| Abstract |
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases. |
X Demographics
The data shown below were collected from the profiles of 104 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 37 | 36% |
| United Kingdom | 10 | 10% |
| Canada | 3 | 3% |
| Saudi Arabia | 3 | 3% |
| Spain | 2 | 2% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Venezuela, Bolivarian Republic of | 1 | <1% |
| Norway | 1 | <1% |
| Other | 9 | 9% |
| Unknown | 36 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 86 | 83% |
| Practitioners (doctors, other healthcare professionals) | 13 | 13% |
| Science communicators (journalists, bloggers, editors) | 4 | 4% |
| Scientists | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 755 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | <1% |
| United States | 3 | <1% |
| Netherlands | 2 | <1% |
| Australia | 2 | <1% |
| Poland | 2 | <1% |
| Spain | 2 | <1% |
| Canada | 2 | <1% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 734 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 150 | 20% |
| Student > Master | 127 | 17% |
| Researcher | 87 | 12% |
| Student > Ph. D. Student | 69 | 9% |
| Other | 59 | 8% |
| Other | 130 | 17% |
| Unknown | 133 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 211 | 28% |
| Agricultural and Biological Sciences | 129 | 17% |
| Nursing and Health Professions | 92 | 12% |
| Biochemistry, Genetics and Molecular Biology | 68 | 9% |
| Immunology and Microbiology | 27 | 4% |
| Other | 82 | 11% |
| Unknown | 146 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 261. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2024.
All research outputs
#141,886
of 25,728,855 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#5
of 722 outputs
Outputs of similar age
#602
of 247,035 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#1
of 11 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 722 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.