| Title |
Radiation-Induced Endothelial Vascular Injury A Review of Possible Mechanisms
|
|---|---|
| Published in |
JACC: Basic to Translational Science, August 2018
|
| DOI | 10.1016/j.jacbts.2018.01.014 |
| Pubmed ID | |
| Authors |
Bhanu Prasad Venkatesulu, Lakshmi Shree Mahadevan, Maureen L. Aliru, Xi Yang, Monica Himaani Bodd, Pankaj K. Singh, Syed Wamique Yusuf, Jun-ichi Abe, Sunil Krishnan |
| Abstract |
In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 11% |
| Venezuela, Bolivarian Republic of | 3 | 11% |
| Spain | 2 | 7% |
| Brazil | 1 | 4% |
| Ecuador | 1 | 4% |
| United Kingdom | 1 | 4% |
| Greece | 1 | 4% |
| Colombia | 1 | 4% |
| Mexico | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 12 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 71% |
| Scientists | 4 | 14% |
| Practitioners (doctors, other healthcare professionals) | 3 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 128 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 16% |
| Student > Bachelor | 16 | 13% |
| Researcher | 15 | 12% |
| Other | 8 | 6% |
| Student > Doctoral Student | 7 | 5% |
| Other | 16 | 13% |
| Unknown | 46 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 22% |
| Biochemistry, Genetics and Molecular Biology | 19 | 15% |
| Agricultural and Biological Sciences | 8 | 6% |
| Physics and Astronomy | 6 | 5% |
| Engineering | 4 | 3% |
| Other | 13 | 10% |
| Unknown | 50 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2024.
All research outputs
#1,394,549
of 25,385,509 outputs
Outputs from JACC: Basic to Translational Science
#121
of 799 outputs
Outputs of similar age
#29,074
of 344,178 outputs
Outputs of similar age from JACC: Basic to Translational Science
#3
of 16 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.