Title |
Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles
|
---|---|
Published in |
Trends in Biotechnology, November 2015
|
DOI | 10.1016/j.tibtech.2015.09.010 |
Pubmed ID | |
Authors |
Man K. Chan, Jason D. Cooper, Sabine Bahn |
Abstract |
Substantial strides have been made in the field of biomarker research for mental illnesses over the past few decades. However, no US FDA-cleared blood-based biomarker tests have been translated into routine clinical practice. Here, we review the challenges associated with commercialisation of research findings and discuss how these challenges can impede scientific impact and progress. Overall evidence indicates that a lack of research funding and poor reproducibility of findings were the most important obstacles to commercialization of biomarker tests. Fraud, pre-analytical and analytical limitations, and inappropriate statistical analysis are major contributors to poor reproducibility. Increasingly, these issues are acknowledged and actions are being taken to improve data validity, raising the hope that robust biomarker tests will become available in the foreseeable future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 22% |
United States | 3 | 17% |
France | 1 | 6% |
Unknown | 10 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 15 | 83% |
Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Scientists | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Student > Master | 9 | 19% |
Student > Bachelor | 6 | 13% |
Researcher | 6 | 13% |
Student > Doctoral Student | 4 | 9% |
Other | 3 | 6% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 19% |
Neuroscience | 6 | 13% |
Psychology | 5 | 11% |
Agricultural and Biological Sciences | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 10 | 21% |
Unknown | 11 | 23% |