| Title |
Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2015
|
| DOI | 10.1007/s00018-015-2083-z |
| Pubmed ID | |
| Authors |
Paige V. Bauer, Sophie C. Hamr, Frank A. Duca |
| Abstract |
Despite significant progress in understanding the homeostatic regulation of energy balance, successful therapeutic options for curbing obesity remain elusive. One potential target for the treatment of obesity is via manipulation of the gut-brain axis, a complex bidirectional communication system that is crucial in maintaining energy homeostasis. Indeed, ingested nutrients induce secretion of gut peptides that act either via paracrine signaling through vagal and non-vagal neuronal relays, or in an endocrine fashion via entry into circulation, to ultimately signal to the central nervous system where appropriate responses are generated. We review here the current hypotheses of nutrient sensing mechanisms of enteroendocrine cells, including the release of gut peptides, mainly cholecystokinin, glucagon-like peptide-1, and peptide YY, and subsequent gut-to-brain signaling pathways promoting a reduction of food intake and an increase in energy expenditure. Furthermore, this review highlights recent research suggesting this energy regulating gut-brain axis can be influenced by gut microbiota, potentially contributing to the development of obesity. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 311 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | <1% |
| Unknown | 310 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 49 | 16% |
| Student > Master | 42 | 14% |
| Student > Ph. D. Student | 41 | 13% |
| Student > Bachelor | 39 | 13% |
| Student > Doctoral Student | 12 | 4% |
| Other | 54 | 17% |
| Unknown | 74 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 55 | 18% |
| Medicine and Dentistry | 53 | 17% |
| Biochemistry, Genetics and Molecular Biology | 34 | 11% |
| Neuroscience | 22 | 7% |
| Nursing and Health Professions | 21 | 7% |
| Other | 32 | 10% |
| Unknown | 94 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2021.
All research outputs
#13,808,503
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,669
of 4,151 outputs
Outputs of similar age
#134,384
of 287,100 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#34
of 58 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.