| Title |
Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury
|
|---|---|
| Published in |
Molecular Neurobiology, November 2015
|
| DOI | 10.1007/s12035-015-9520-8 |
| Pubmed ID | |
| Authors |
P. M. Abdul-Muneer, Bryan J. Pfister, James Haorah, Namas Chandra |
| Abstract |
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Studies revealed that the pathogenesis of TBI involves upregulation of MMPs. MMPs form a large family of closely related zinc-dependent endopeptidases, which are primarily responsible for the dynamic remodulation of the extracellular matrix (ECM). Thus, they are involved in several normal physiological processes like growth, development, and wound healing. During pathophysiological conditions, MMPs proteolytically degrade various components of ECM and tight junction (TJ) proteins of BBB and cause BBB disruption. Impairment of BBB causes leakiness of the blood from circulation to brain parenchyma that leads to microhemorrhage and edema. Further, MMPs dysregulate various normal physiological processes like angiogenesis and neurogenesis, and also they participate in the inflammatory and apoptotic cascades by inducing or regulating the specific mediators and their receptors. In this review, we explore the roles of MMPs in various physiological/pathophysiological processes associated with neurological complications, with special emphasis on TBI. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 25% |
| Researcher | 7 | 9% |
| Other | 5 | 7% |
| Student > Doctoral Student | 5 | 7% |
| Student > Bachelor | 5 | 7% |
| Other | 11 | 15% |
| Unknown | 23 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 21% |
| Medicine and Dentistry | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Engineering | 5 | 7% |
| Agricultural and Biological Sciences | 5 | 7% |
| Other | 6 | 8% |
| Unknown | 29 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2023.
All research outputs
#6,248,939
of 24,784,213 outputs
Outputs from Molecular Neurobiology
#1,293
of 3,788 outputs
Outputs of similar age
#73,502
of 291,313 outputs
Outputs of similar age from Molecular Neurobiology
#42
of 135 outputs
Altmetric has tracked 24,784,213 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,788 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
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We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.