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Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis

Overview of attention for article published in European journal of gastroenterology & hepatology, February 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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31 X users
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4 Wikipedia pages

Citations

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44 Dimensions

Readers on

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40 Mendeley
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Title
Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis
Published in
European journal of gastroenterology & hepatology, February 2016
DOI 10.1097/meg.0000000000000496
Pubmed ID
Authors

Stephanie Y. Lee, Mohammad M. Jamal, Emily T. Nguyen, Matthew L. Bechtold, Douglas L. Nguyen

Abstract

Isotretinoin is a treatment option for severe nodulocystic acne. However, its use has inconsistently been associated with the development of inflammatory bowel disease (IBD). This meta-analysis aims to elucidate the association between isotretinoin exposure and the risk for IBD. A comprehensive search of PubMed/MEDLINE, CINAHL, the Cochrane database, and Google Scholar was performed (July 2015). All studies on the development of IBD in patients with or without prior exposure to isotretinoin, along with control participants, were included. Meta-analysis was carried out using the Mantel-Haenszel random effect model to assess the risk for IBD in the context of prior isotretinoin exposure. In a pooled analysis of six research studies, there was no increased risk of developing IBD in patients exposed to isotretinoin compared with patients not exposed to isotretinoin [odds ratio (OR) 1.08, 95% confidence interval (CI) 0.82, 1.42, P=0.59]. Furthermore, there was no increased risk of developing Crohn's disease (OR 0.98, 95% CI 0.62, 1.55, P=0.93, I=62%) or ulcerative colitis (OR 1.14, 95% CI 0.79, 1.63, P=0.49, I=44%) in patients exposed to isotretinoin compared with those not exposed to the medication. Isotretinoin exposure is not associated with an increased risk of developing both ulcerative colitis and Crohn's disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 18%
Student > Master 6 15%
Student > Doctoral Student 4 10%
Unspecified 2 5%
Student > Postgraduate 2 5%
Other 6 15%
Unknown 13 33%
Readers by discipline Count As %
Medicine and Dentistry 13 33%
Unspecified 2 5%
Computer Science 2 5%
Nursing and Health Professions 1 3%
Agricultural and Biological Sciences 1 3%
Other 5 13%
Unknown 16 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2023.
All research outputs
#1,697,741
of 25,373,627 outputs
Outputs from European journal of gastroenterology & hepatology
#61
of 2,478 outputs
Outputs of similar age
#29,600
of 406,420 outputs
Outputs of similar age from European journal of gastroenterology & hepatology
#1
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,478 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.