| Title |
A Comprehensive Review on l-Asparaginase and Its Applications
|
|---|---|
| Published in |
Applied Biochemistry and Biotechnology, November 2015
|
| DOI | 10.1007/s12010-015-1917-3 |
| Pubmed ID | |
| Authors |
Tahira Batool, Essam A. Makky, Muna Jalal, Mashitah M. Yusoff |
| Abstract |
L-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. Owing to its ability to inhibit protein biosynthesis in lymphoblasts, LA is used to treat acute lymphoblastic leukemia (ALL). Different isozymes of this enzyme have been isolated from a wide range of organisms, including plants and terrestrial and marine microorganisms. Pieces of information about the three-dimensional structure of L-asparaginase from Escherichia coli and Erwinia sp. have identified residues that are essential for catalytic activity. This review catalogues the major sources of L-asparaginase, the methods of its production through the solid state (SSF) and submerged (SmF) fermentation, purification, and characterization as well as its biological roles. In the same breath, this article explores both the past and present applications of this important enzyme and discusses its future prospects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 474 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Russia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 470 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 77 | 16% |
| Student > Ph. D. Student | 57 | 12% |
| Student > Master | 56 | 12% |
| Researcher | 37 | 8% |
| Student > Doctoral Student | 16 | 3% |
| Other | 57 | 12% |
| Unknown | 174 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 110 | 23% |
| Agricultural and Biological Sciences | 48 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 5% |
| Immunology and Microbiology | 23 | 5% |
| Medicine and Dentistry | 23 | 5% |
| Other | 56 | 12% |
| Unknown | 189 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2018.
All research outputs
#3,200,780
of 22,832,057 outputs
Outputs from Applied Biochemistry and Biotechnology
#70
of 2,507 outputs
Outputs of similar age
#47,981
of 285,879 outputs
Outputs of similar age from Applied Biochemistry and Biotechnology
#1
of 35 outputs
Altmetric has tracked 22,832,057 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,507 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.