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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
|
|---|---|
| Published in |
Cancer Cell, November 2015
|
| DOI | 10.1016/j.ccell.2015.09.021 |
| Pubmed ID | |
| Authors |
Chunming Cheng, Peng Ru, Feng Geng, Junfeng Liu, Ji Young Yoo, Xiaoning Wu, Xiang Cheng, Vanessa Euthine, Peng Hu, Jeffrey Yunhua Guo, Etienne Lefai, Balveen Kaur, Axel Nohturfft, Jianjie Ma, Arnab Chakravarti, Deliang Guo |
| Abstract |
Tumorigenesis is associated with increased glucose consumption and lipogenesis, but how these pathways are interlinked is unclear. Here, we delineate a pathway in which EGFR signaling, by increasing glucose uptake, promotes N-glycosylation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and consequent activation of SREBP-1, an ER-bound transcription factor with central roles in lipid metabolism. Glycosylation stabilizes SCAP and reduces its association with Insig-1, allowing movement of SCAP/SREBP to the Golgi and consequent proteolytic activation of SREBP. Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth. Thus, SCAP acts as key glucose-responsive protein linking oncogenic signaling and fuel availability to SREBP-dependent lipogenesis. Targeting SCAP N-glycosylation may provide a promising means of treating malignancies and metabolic diseases. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 26% |
| Austria | 1 | 4% |
| India | 1 | 4% |
| Brazil | 1 | 4% |
| Saudi Arabia | 1 | 4% |
| Unknown | 13 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 74% |
| Practitioners (doctors, other healthcare professionals) | 3 | 13% |
| Scientists | 3 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 162 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 23% |
| Researcher | 26 | 16% |
| Student > Bachelor | 17 | 10% |
| Student > Master | 13 | 8% |
| Student > Doctoral Student | 12 | 7% |
| Other | 20 | 12% |
| Unknown | 38 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 34% |
| Agricultural and Biological Sciences | 26 | 16% |
| Medicine and Dentistry | 14 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Immunology and Microbiology | 4 | 2% |
| Other | 11 | 7% |
| Unknown | 47 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2022.
All research outputs
#2,282,570
of 25,374,647 outputs
Outputs from Cancer Cell
#1,407
of 3,149 outputs
Outputs of similar age
#32,053
of 294,815 outputs
Outputs of similar age from Cancer Cell
#23
of 44 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,815 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.